SETD8 monomethylates histone H4

Stable Identifier
R-HSA-2301205
Type
Reaction
Species
Homo sapiens
Compartment
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SETD8 is a protein-lysine N-methyltransferase that monomethylates H4 histone to produce H4K20me1 (Nishioka et al. 2002, Wu et al. 2010). SETD8 levels peak at G2/M transition, and regulated SETD8 activity is required for normal cell cycle progression (Rice et al. 2002, Wu et al. 2010).

Literature References
PubMed ID Title Journal Year
12086618 PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin

Rice, JC, Nishioka, K, Lis, JT, Tempst, P, Werner, J, Allis, CD, Erdjument-Bromage, H, Reinberg, D, Valenzuela, P, Chuikov, S, Steward, R, Sarma, K, Wang, Y

Mol. Cell 2002
20966048 Dynamic regulation of the PR-Set7 histone methyltransferase is required for normal cell cycle progression

Rice, JC, Yokomori, K, Wu, S, Wang, W, Kirschner, MW, Congdon, LM, Kong, X

Genes Dev. 2010
12208845 Mitotic-specific methylation of histone H4 Lys 20 follows increased PR-Set7 expression and its localization to mitotic chromosomes

Rice, JC, Nishioka, K, Reinberg, D, Steward, R, Sarma, K, Allis, CD

Genes Dev. 2002
Participants
Participates
Catalyst Activity

histone methyltransferase activity (H4-K20 specific) of SETD8 [nucleoplasm]

Orthologous Events
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