SETD8 monomethylates histone H4

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

SETD8 is a protein-lysine N-methyltransferase that monomethylates H4 histone to produce H4K20me1 (Nishioka et al. 2002, Wu et al. 2010). SETD8 levels peak at G2/M transition, and regulated SETD8 activity is required for normal cell cycle progression (Rice et al. 2002, Wu et al. 2010).

Literature References
PubMed ID Title Journal Year
20966048 Dynamic regulation of the PR-Set7 histone methyltransferase is required for normal cell cycle progression

Wu, S, Wang, W, Kong, X, Congdon, LM, Yokomori, K, Kirschner, MW, Rice, JC

Genes Dev. 2010
12086618 PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin

Nishioka, K, Rice, JC, Sarma, K, Erdjument-Bromage, H, Werner, J, Wang, Y, Chuikov, S, Valenzuela, P, Tempst, P, Steward, R, Lis, JT, Allis, CD, Reinberg, D

Mol. Cell 2002
12208845 Mitotic-specific methylation of histone H4 Lys 20 follows increased PR-Set7 expression and its localization to mitotic chromosomes

Rice, JC, Nishioka, K, Sarma, K, Steward, R, Reinberg, D, Allis, CD

Genes Dev. 2002
Participant Of
Catalyst Activity
Catalyst Activity
histone methyltransferase activity (H4-K20 specific) of SETD8 [nucleoplasm]
Physical Entity
Orthologous Events
Cite Us!