SETD8 monomethylates histone H4

Stable Identifier
Homo sapiens
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SETD8 is a protein-lysine N-methyltransferase that monomethylates H4 histone to produce H4K20me1 (Nishioka et al. 2002, Wu et al. 2010). SETD8 levels peak at G2/M transition, and regulated SETD8 activity is required for normal cell cycle progression (Rice et al. 2002, Wu et al. 2010).

Literature References
PubMed ID Title Journal Year
12086618 PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin

Rice, JC, Nishioka, K, Lis, JT, Tempst, P, Werner, J, Allis, CD, Erdjument-Bromage, H, Reinberg, D, Valenzuela, P, Chuikov, S, Steward, R, Sarma, K, Wang, Y

Mol. Cell 2002
20966048 Dynamic regulation of the PR-Set7 histone methyltransferase is required for normal cell cycle progression

Rice, JC, Yokomori, K, Wu, S, Wang, W, Kirschner, MW, Congdon, LM, Kong, X

Genes Dev. 2010
12208845 Mitotic-specific methylation of histone H4 Lys 20 follows increased PR-Set7 expression and its localization to mitotic chromosomes

Rice, JC, Nishioka, K, Reinberg, D, Steward, R, Sarma, K, Allis, CD

Genes Dev. 2002
Catalyst Activity

histone methyltransferase activity (H4-K20 specific) of SETD8 [nucleoplasm]

Orthologous Events
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