Reactome | SETD8 monomethylates histone H4

SETD8 monomethylates histone H4

Stable Identifier

R-HSA-2301205

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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SETD8 is a protein-lysine N-methyltransferase that monomethylates H4 histone to produce H4K20me1 (Nishioka et al. 2002, Wu et al. 2010). SETD8 levels peak at G2/M transition, and regulated SETD8 activity is required for normal cell cycle progression (Rice et al. 2002, Wu et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
12086618	PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin Nishioka, K, Rice, JC, Sarma, K, Erdjument-Bromage, H, Werner, J, Wang, Y, Chuikov, S, Valenzuela, P, Tempst, P, Steward, R, Lis, JT, Allis, CD, Reinberg, D	Mol. Cell	2002
20966048	Dynamic regulation of the PR-Set7 histone methyltransferase is required for normal cell cycle progression Wu, S, Wang, W, Kong, X, Congdon, LM, Yokomori, K, Kirschner, MW, Rice, JC	Genes Dev.	2010
12208845	Mitotic-specific methylation of histone H4 Lys 20 follows increased PR-Set7 expression and its localization to mitotic chromosomes Rice, JC, Nishioka, K, Sarma, K, Steward, R, Reinberg, D, Allis, CD	Genes Dev.	2002