Reactome | KCNH1 [plasma membrane]

KCNH1 [plasma membrane]

Stable Identifier

R-HSA-2291883

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Potassium voltage-gated channel subfamily H member 1, Q14CL3_HUMAN

Locations in the PathwayBrowser

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Neuronal System (Homo sapiens)

- Potassium Channels (Homo sapiens)
  - Voltage gated Potassium channels (Homo sapiens)
    - Activation of voltage gated Potassium channels (Homo sapiens)
      - Octamer of Voltage gated K+ channels [plasma membrane] (Homo sapiens)
        
        Voltage gated potassium channel subunits Kv1-12 [plasma membrane] (Homo sapiens)
        
        Kv10 subunits of voltage gated potassium channels [plasma membrane] (Homo sapiens)
        
        KCNH1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O95259 KCNH1

Gene Names

KCNH1, EAG, EAG1

Chain

chain:1-989

Reference Genes

BioGPS Gene:3756 KCNH1

COSMIC (genes):KCNH1 KCNH1

CTD Gene:3756 KCNH1

dbSNP Gene:3756 KCNH1

ENSEMBL:ENSG00000143473 KCNH1

HGNC:6250 KCNH1

Monarch:3756 KCNH1

NCBI Gene:3756 KCNH1

OMIM:603305 KCNH1

UCSC:O95259 KCNH1

Reference Transcript

Other Identifiers

11725671_a_at

11735587_a_at

11738518_a_at

16698949

207635_PM_s_at

207635_s_at

2454141

2454142

2454143

2454174

2454175

2454176

2454184

2454185

2454192

2454193

2454194

2454195

2454209

2454210

2454218

2454219

2454222

2454225

2454226

2454229

2454234

2454235

2454240

2454241

2454246

2454248

2454250

2454252

2454254

2454256

2454258

2454260

2454262

2454264

2454266

2454268

2454270

33087_s_at

33088_at

3319868

3319872

3319873

3319882

3319886

3505681

3505695

3756

4008541

7924071

A_23_P74943

A_32_P186226

GE79576

GE801671

GE80843

GO:0005215

GO:0005216

GO:0005249

GO:0005251

GO:0005267

GO:0005515

GO:0005516

GO:0005634

GO:0005637

GO:0005768

GO:0005886

GO:0006811

GO:0006813

GO:0007520

GO:0008076

GO:0008289

GO:0016020

GO:0030424

GO:0030425

GO:0031410

GO:0031901

GO:0034220

GO:0034702

GO:0042127

GO:0042391

GO:0042734

GO:0042995

GO:0043204

GO:0043226

GO:0043231

GO:0045202

GO:0045211

GO:0055085

GO:0071277

GO:0071805

GO:0098839

GO:1902936

HMNXSV003022173

HMNXSV003056136

ILMN_1745529

ILMN_1891067

ILMN_2299862

PH_hs_0009585

TC01003791.hg

TC01006085.hg

g4504830_3p_a_at

Participates

as a member of

Kv10 subunits of voltage gated potassium channels [plasma membrane] (Homo sapiens)

Inferred To

kcnh1 [plasma membrane] (Xenopus tropicalis)

KCNH1 [plasma membrane] (Bos taurus)

KCNH1 [plasma membrane] (Canis familiaris)

KCNH1 [plasma membrane] (Drosophila melanogaster)

KCNH1 [plasma membrane] (Gallus gallus)

KCNH1 [plasma membrane] (Sus scrofa)

Kcnh1 [plasma membrane] (Mus musculus)

Kcnh1 [plasma membrane] (Rattus norvegicus)

Cross References

Guide to Pharmacology - Targets

570

ENSEMBL

ENST00000639952, ENSP00000271751, ENSP00000492513, ENSP00000491725, ENST00000640710, ENSP00000492302, ENSP00000492697, ENST00000638960, ENST00000640528, ENST00000271751

OpenTargets

ENSG00000143473

HPA

ENSG00000143473-KCNH1

PRO

O95259

Pharos - Targets

O95259

GlyGen

O95259

Orphanet

KCNH1

HMDB Protein

HMDBP08142

PDB

5J7E

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O00560 SDCBP	3	SDCBP [cytosol] (R-HSA-373639) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [extracellular region] (R-HSA-6806206)	0.556	3
UniProt:Q7L8L6 FASTKD5	1	FASTKD5 [mitochondrial matrix] (R-HSA-9837206)	0.556	3