Reactome | KCNH1 [plasma membrane]

KCNH1 [plasma membrane]

Stable Identifier

R-HSA-2291883

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Potassium voltage-gated channel subfamily H member 1, Q14CL3_HUMAN

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Potassium Channels (Homo sapiens)
  - Voltage gated Potassium channels (Homo sapiens)
    - Activation of voltage gated Potassium channels (Homo sapiens)
      - Octamer of Voltage gated K+ channels [plasma membrane] (Homo sapiens)
        
        Voltage gated potassium channel subunits Kv1-12 [plasma membrane] (Homo sapiens)
        
        Kv10 subunits of voltage gated potassium channels [plasma membrane] (Homo sapiens)
        
        KCNH1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O95259 KCNH1

Gene Names

KCNH1, EAG, EAG1

Chain

chain:1-989

Reference Genes

BioGPS Gene:3756 KCNH1

COSMIC (genes):KCNH1 KCNH1

CTD Gene:3756 KCNH1

dbSNP Gene:3756 KCNH1

ENSEMBL:ENSG00000143473 KCNH1

HGNC:6250 KCNH1

KEGG Gene (Homo sapiens):3756 KCNH1

Monarch:3756 KCNH1

NCBI Gene:3756 KCNH1

OMIM:603305 KCNH1

UCSC:O95259 KCNH1

Reference Transcript

Other Identifiers

0003850400

0005900377

11735587_a_at

11738518_a_at

16698949

207635_s_at

2454141

2454142

2454143

2454174

2454175

2454176

2454184

2454185

2454210

2454218

2454219

2454222

2454225

2454226

2454229

2454234

2454235

33087_s_at

33088_at

3756

7924071

A_23_P74943

GE801671

GE80843

GO:0001964

GO:0003674

GO:0005216

GO:0005244

GO:0005249

GO:0005251

GO:0005267

GO:0005515

GO:0005516

GO:0005575

GO:0005622

GO:0005634

GO:0005635

GO:0005637

GO:0005737

GO:0005768

GO:0005886

GO:0005887

GO:0006810

GO:0006811

GO:0006813

GO:0007165

GO:0007520

GO:0008076

GO:0008150

GO:0008283

GO:0008289

GO:0009986

GO:0016020

GO:0016021

GO:0019899

GO:0019901

GO:0022857

GO:0030054

GO:0030154

GO:0030424

GO:0030425

GO:0030673

GO:0031410

GO:0031901

GO:0032991

GO:0034220

GO:0034705

GO:0034765

GO:0042127

GO:0042391

GO:0042734

GO:0042802

GO:0042995

GO:0043025

GO:0043167

GO:0043204

GO:0043226

GO:0043231

GO:0044325

GO:0044877

GO:0045202

GO:0045211

GO:0048015

GO:0048471

GO:0048646

GO:0048856

GO:0050877

GO:0055085

GO:0071277

GO:0071805

GO:0071889

GO:0098839

GO:0099056

GO:1902936

HMNXSV003022173

ILMN_1745529

ILMN_1811354

ILMN_1827900

ILMN_1891067

ILMN_2299862

PH_hs_0009585

TC01003791.hg

TC01006085.hg

g4504830_3p_a_at

Participates

as a member of

Kv10 subunits of voltage gated potassium channels [plasma membrane] (Homo sapiens)

Inferred To

KCNH1 [plasma membrane] (Canis familiaris)

KCNH1 [plasma membrane] (Gallus gallus)

KCNH1 [plasma membrane] (Sus scrofa)

Kcnh1 [plasma membrane] (Mus musculus)

Kcnh1 [plasma membrane] (Rattus norvegicus)

eag [plasma membrane] (Drosophila melanogaster)

kcnh1b [plasma membrane] (Danio rerio)

Homologues of KCNH1 [plasma membrane] (Danio rerio)

kcnh1a [plasma membrane] (Danio rerio)

Cross References

RefSeq

NP_758872.1, NP_002229.1

Guide to Pharmacology - Targets

570

OpenTargets

ENSG00000143473

GeneCards

O95259

HPA

ENSG00000143473-KCNH1

Ensembl

ENSG00000143473, ENSP00000492513, ENST00000638960, ENST00000271751, ENST00000640528, ENST00000640710, ENSP00000271751, ENSP00000492302, ENSP00000492697, ENST00000639952, ENSP00000491725

PRO

O95259

Pharos - Targets

O95259

GlyGen

O95259

Orphanet

23250

HMDB Protein

HMDBP08142

PDB

5J7E

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [cytosol] (R-HSA-373639)	0.556	3