Reactome | Interaction of DAP12 and KIR2DS1

Interaction of DAP12 and KIR2DS1

Stable Identifier

R-HSA-2272795

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Killer cell immunoglobulin-like two-domain short-tail receptor 1 (KIR2DS1) is one of the activating KIR receptors expressed on the surface of NK cells. It recognizes and binds to ligand HLA-C2:peptide complexes. KIR2DS1 oligomerizes upon interaction with its HLA-Class I ligands. The interaction between the peptide-HLA and KIR2DS1 oligomers leads to activation of the DAP12 signaling cascade. The engagement of KIR2DS1 with HLA-C2 is not sufficient to drive NK cell cytotoxicity or IFN-gamma production (Stewart et al. 2005). Recognition of HLA-C2 by KIR2DS1 is involved in the anti-leukemic activity of alloreactive NK cells and associated with protection against Hodgkin's lymphoma (Cognet et al. 2010). The presence of the HLA-C2 allele HLA-Cw6 in combination with KIR2DS1 is a major risk factor for psoriasis (Ploski et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
20093094	Expression of the HLA-C2-specific activating killer-cell Ig-like receptor KIR2DS1 on NK and T cells Gauthier, L, Rieux-Laucat, F, Magérus-Chatinet, A, André, P, Farnarier, C, Schleinitz, N, Cognet, C, Vivier, E, Anfossi, N, Frassati, C	Clin. Immunol.	2010