Reactome | Interaction of DAP12 and KIR2DS4

Interaction of DAP12 and KIR2DS4

Stable Identifier

R-HSA-2272753

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Killer cell immunoglobulin-like two-domain short-tail receptor 4 (KIR2DS4) is the most prevalent lineage III-activating KIR receptor. It interacts weakly but specifically with HLA-Cw3 and HLA-Cw4 and may also bind to an uncharacterised non-MHC molecule. It can associate with DAP12, activating NK cells.

Literature References

PubMed ID	Title	Journal	Year
19858347	KIR2DS4 is a product of gene conversion with KIR3DL2 that introduced specificity for HLA-A*11 while diminishing avidity for HLA-C Norman, PJ, Abi-Rached, L, Hammond, JA, Graef, T, Parham, P, Robinson, PJ, Vago, L, Moesta, AK, Bushnell, DA, Guethlein, LA, Older Aguilar, AM, Gleimer, M	J. Exp. Med.	2009
15265913	MHC class I-independent recognition of NK-activating receptor KIR2DS4 Tarcic, G, Mandelboim, O, Drize, O, Achdout, H, Merims, S, Gruda, R, Katz, G, Markel, G, Gazit, R, Gonen-Gross, T, Arnon, TI	J. Immunol.	2004