RAB8A/10/13/14 release GDP and bind GTP to yield the active complex. Guanine nucleotide exchange factors (GEFs) stimulate the reaction. GTPase-activating proteins (GAPs) oppose the reaction by stimulating the intrinsic GTPase activity of the RAB proteins.
Linford, A, Rigden, DJ, Barr, FA, Gerondopoulos, A, Yoshimura, S
Peranen, J, Murga-Zamalloa, CA, Khanna, H, Swaroop, A, Atkins, SJ
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