RAB8A,10,13,14 exchange GDP for GTP

Stable Identifier
R-HSA-2255343
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytoplasmic vesicle membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
RAB8A,10,13,14 exchange GDP for GTP
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

RAB8A/10/13/14 release GDP and bind GTP to yield the active complex. Guanine nucleotide exchange factors (GEFs) stimulate the reaction. GTPase-activating proteins (GAPs) oppose the reaction by stimulating the intrinsic GTPase activity of the RAB proteins.

Literature References
PubMed ID Title Journal Year
20631154 Interaction of retinitis pigmentosa GTPase regulator (RPGR) with RAB8A GTPase: implications for cilia dysfunction and photoreceptor degeneration

Murga-Zamalloa, CA, Atkins, SJ, Peranen, J, Swaroop, A, Khanna, H

Hum. Mol. Genet. 2010
20937701 Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors

Yoshimura, S, Gerondopoulos, A, Linford, A, Rigden, DJ, Barr, FA

J. Cell Biol. 2010
Participants
Input
Output
Participant Of
hasEvent
Inferred From
Rab8A/13/14 Exchange GDP for GTP (Rattus norvegicus)
Rab8A/10/13/14 Exchange GDP for GTP (Mus musculus)
Authored
May, B  (2012-05-16)
Reviewed
Klip, A  (2012-08-21)
Created
May, B  (2012-05-19)