RAB8A,10,13,14 exchange GDP for GTP

Stable Identifier
R-HSA-2255343
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytoplasmic vesicle membrane
ReviewStatus
5/5
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RAB8A,10,13,14 exchange GDP for GTP
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RAB8A/10/13/14 release GDP and bind GTP to yield the active complex. Guanine nucleotide exchange factors (GEFs) stimulate the reaction. GTPase-activating proteins (GAPs) oppose the reaction by stimulating the intrinsic GTPase activity of the RAB proteins.
Literature References
PubMed ID Title Journal Year
20937701 Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors

Yoshimura, S, Gerondopoulos, A, Linford, A, Rigden, DJ, Barr, FA

J. Cell Biol. 2010
20631154 Interaction of retinitis pigmentosa GTPase regulator (RPGR) with RAB8A GTPase: implications for cilia dysfunction and photoreceptor degeneration

Murga-Zamalloa, CA, Atkins, SJ, Peranen, J, Swaroop, A, Khanna, H

Hum. Mol. Genet. 2010
Participants
Input
Output
Participates
as an event of
Inferred From
Rab8A/10/13/14 Exchange GDP for GTP (Mus musculus)
Rab8A/13/14 Exchange GDP for GTP (Rattus norvegicus)
Authored
May, B  (2012-05-16)
Reviewed
Klip, A  (2012-08-21)
Created
May, B  (2012-05-19)
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