RALA exchanges GDP for GTP

Stable Identifier
R-HSA-2255342
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytoplasmic vesicle membrane
Synonyms
Activation of RALA
ReviewStatus
5/5
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RALA exchanges GDP for GTP
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RALA releases GDP and binds GTP, producing the active form of RALA. The reaction is accelerated by guanine nucleotide exchange factors (GEFs) and opposed by GTPase-activating proteins (GAPs) which enhance the conversion of RALA:GTP back to RALA:GDP by activating the GTPase activity of RALA.
Literature References
PubMed ID Title Journal Year
2550440 Identification of the ral and rac1 gene products, low molecular mass GTP-binding proteins from human platelets

Weber, RF, Snyderman, R, Evans, T, Didsbury, JR, Polakis, PG, Nevins, B

J. Biol. Chem. 1989
8094051 Characterization of a guanine nucleotide dissociation stimulator for a ras-related GTPase

Weinberg, RA, Liu, J, Albright, CF, Giddings, BW, Vito, M

EMBO J. 1993
Participants
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as an event of
Inferred From
RalA Exchanges GDP for GTP (Mus musculus)
Authored
May, B  (2012-05-16)
Reviewed
Klip, A  (2012-08-21)
Created
May, B  (2012-05-19)
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