Reactome | Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed

Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed

Stable Identifier

R-HSA-2247512

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

endocytic vesicle membrane, plasma membrane

ReviewStatus

5/5

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Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed

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The Platelet glycoprotein IV (CD36):ligand complex is endocytosed (Zeng et al. 2003, McDermott_Roe et al. 2008, Nilsen et al. 2008, Collins et al. 2009). The endocytosis of CD36:oxidized LDL is independent of caveolin (Zeng et al. 2003) and dependent on actin (Collins et al. 2009). As inferred from mouse, endocytosis of CD36:oxidized LDL is independent of caveolae, microtubules, and actin cytoskeleton, but dependent on dynamin (Sun et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17876058	Distinct mechanisms for OxLDL uptake and cellular trafficking by class B scavenger receptors CD36 and SR-BI Shridas, P, Sun, B, Connelly, MA, Boyanovsky, BB, van der Westhuyzen, DR, Webb, NR	J. Lipid Res.	2007
19740737	Uptake of oxidized low density lipoprotein by CD36 occurs by an actin-dependent pathway distinct from macropinocytosis Trimble, WS, Kuwata, H, Collins, RF, Tandon, NN, Grinstein, S, Touret, N	J Biol Chem	2009
12947091	Endocytosis of oxidized low density lipoprotein through scavenger receptor CD36 utilizes a lipid raft pathway that does not require caveolin-1 Chung, KN, Tao, N, Lublin, DM, Zeng, Y, Heuser, JE	J Biol Chem	2003
18458151	Cellular trafficking of lipoteichoic acid and Toll-like receptor 2 in relation to signaling: role of CD14 and CD36 Lien, E, Deininger, S, Husebye, H, Hartung, T, Nilsen, NJ, von Aulock, S, Rodionov, D, Skjeldal, F, Nonstad, U, Bakke, O, Espevik, T	J Leukoc Biol	2008
18558917	CD36 N-terminal cytoplasmic domain is not required for the internalization of oxidized low-density lipoprotein Martin, J, McDermott-Roe, C, Collot-Teixeira, S, McGregor, JL	Biosci Rep	2008