Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed

Stable Identifier
R-HSA-2247512
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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The Platelet glycoprotein IV (CD36):ligand complex is endocytosed (Zeng et al. 2003, McDermott_Roe et al. 2008, Nilsen et al. 2008, Collins et al. 2009). The endocytosis of CD36:oxidized LDL is independent of caveolin (Zeng et al. 2003) and dependent on actin (Collins et al. 2009). As inferred from mouse, endocytosis of CD36:oxidized LDL is independent of caveolae, microtubules, and actin cytoskeleton, but dependent on dynamin (Sun et al. 2007).

Literature References
PubMed ID Title Journal Year
19740737 Uptake of oxidized low density lipoprotein by CD36 occurs by an actin-dependent pathway distinct from macropinocytosis

Collins, RF, Touret, N, Kuwata, H, Tandon, NN, Grinstein, S, Trimble, WS

J Biol Chem 2009
17876058 Distinct mechanisms for OxLDL uptake and cellular trafficking by class B scavenger receptors CD36 and SR-BI

Sun, B, Boyanovsky, BB, Connelly, MA, Shridas, P, van der Westhuyzen, DR, Webb, NR

J. Lipid Res. 2007
12947091 Endocytosis of oxidized low density lipoprotein through scavenger receptor CD36 utilizes a lipid raft pathway that does not require caveolin-1

Zeng, Y, Tao, N, Chung, KN, Heuser, JE, Lublin, DM

J Biol Chem 2003
18458151 Cellular trafficking of lipoteichoic acid and Toll-like receptor 2 in relation to signaling: role of CD14 and CD36

Nilsen, NJ, Deininger, S, Nonstad, U, Skjeldal, F, Husebye, H, Rodionov, D, von Aulock, S, Hartung, T, Lien, E, Bakke, O, Espevik, T

J Leukoc Biol 2008
18558917 CD36 N-terminal cytoplasmic domain is not required for the internalization of oxidized low-density lipoprotein

McDermott-Roe, C, Martin, J, Collot-Teixeira, S, McGregor, JL

Biosci Rep 2008
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