Reactome | p-S69,120-PHF8-1 [nucleoplasm]

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p-S69,120-PHF8-1

Stable Identifier

R-HSA-2245211

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Prophase (Homo sapiens)
      - Condensation of Prophase Chromosomes (Homo sapiens)
        
        CDK1 phosphorylates PHF8 (Homo sapiens)
        
        p-2S-PHF8:Fe2+ [nucleoplasm] (Homo sapiens)
        
        p-2S-PHF8 [nucleoplasm] (Homo sapiens)
        
        p-S69,120-PHF8-1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UPP1-1 PHF8

Gene Names

PHF8, KIAA1111, ZNF422

Other Identifiers

0004120341

11719423_at

11756084_a_at

17111366

212916_at

23133

2WWU

38779

3K3N

3K3O

3KV4

41399_at

4DO0

62015

8173009

A_23_P9744

A_24_P130865

A_24_P942253

A_33_P3361925

AAH53861

AB029034

AK021696

AK022788

AK304272

AL589872

AL732374

BAA83063

BAB13877

BAG51116

BAH14147

BC042108

BC053861

CAI45929

CCDS14355

CCDS55418

CCDS55419

CCDS55420

CR933612

ENSG00000172943

ENSP00000319473

ENSP00000338868

ENSP00000340051

ENSP00000350676

ENST00000322659

ENST00000338154

ENST00000338946

ENST00000357988

EntrezGene:23133

GO:0000082

GO:0000278

GO:0003674

GO:0003682

GO:0005506

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005635

GO:0005654

GO:0005730

GO:0006351

GO:0006355

GO:0006464

GO:0007049

GO:0007420

GO:0008150

GO:0008270

GO:0009058

GO:0016491

GO:0016569

GO:0016706

GO:0031965

GO:0032452

GO:0032454

GO:0033169

GO:0034641

GO:0035064

GO:0035574

GO:0035575

GO:0042393

GO:0043167

GO:0043226

GO:0045893

GO:0045943

GO:0046872

GO:0048856

GO:0051213

GO:0051276

GO:0051864

GO:0055114

GO:0061188

GO:0070544

GO:0071557

GO:0071558

HGNC:20672

HPA038779

HPA062015

Hs.133352

Hs.285641.0.S1_3p_at

ILMN_1711318

ILMN_1762169

ILMN_2230530

IPR001965

IPR003347

IPR011011

IPR013083

IPR019786

IPR019787

NM_001184896

NM_001184897

NM_001184898

NM_015107

NP_001171825

NP_001171826

NP_001171827

NP_055922

PF00628

PF02373

PH_hs_0022505

PHF8

PHF8-201

PHF8-202

PHF8-203

PHF8-204

SM00249

SM00558

TC0X001070.hg

uc004dst.4

uc004dsu.4

uc004dsw.4

uc004dsy.4

UPI00001A9CA8

UPI00001C2071

UPI00004A3B10

UPI00019154B7

XM_005261996

XM_005261997

XM_005261999

XM_005262000

XM_011530778

XM_017029361

XM_017029362

XP_005262053

XP_005262054

XP_005262056

XP_005262057

XP_011529080

XP_016884850

XP_016884851

Z98051

Participant Of

hasCandidate

p-2S-PHF8 [nucleoplasm]

Other forms of this molecule

PHF8-1 [nucleoplasm]

Inferred To

phospho-p-S69,120-PHF8-1 [nucleoplasm] (Bos taurus)

phospho-p-S69,120-PHF8-1 [nucleoplasm] (Caenorhabditis elegans)

phospho-p-S69,120-PHF8-1 [nucleoplasm] (Canis familiaris)

phospho-p-S69,120-PHF8-1 [nucleoplasm] (Saccharomyces cerevisiae)

Homologues of p-S69,120-PHF8-1 [nucleoplasm] (Caenorhabditis elegans)

Homologues of p-S69,120-PHF8-1 [nucleoplasm] (Canis familiaris)

Modified Residues

Name

O-phospho-L-serine at 69

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 120

Coordinate

120

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_001171825.1, XP_016884851.1, NP_055922.1, NP_001171826.1

ZINC - Metabolites

PHF8_HUMAN

Brenda

1.14.11.27

ZINC - Substances

PHF8_HUMAN

GeneCards

Q9UPP1

ZINC - Biogenic

PHF8_HUMAN

ZINC target

Q9UPP1

PRO

Q9UPP1

Orphanet

16818

ZINC - Predictions - Purchasable

PHF8_HUMAN

PDB

2WWU, 3K3N, 4DO0, 3KV4, 3K3O

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q01094 E2F1	2	p-E2F1 [nucleoplasm] (R-HSA-187911) E2F1 [nucleoplasm] (R-HSA-68639)	0.499	2
UniProt:Q06330 RBPJ	1	RBPJ [nucleoplasm] (R-HSA-3008668)	0.499	2
UniProt:P46531 NOTCH1	60	NOTCH1 I1680N S2 cleavage fragment [extracellular region] (R-HSA-2730744) NOTCH1 L1678P S2 cleavage fragment [extracellular region] (R-HSA-2730745) NOTCH1 I1718T S2 cleavage fragment [extracellular region] (R-HSA-2730757) NOTCH1 A1701P S2 cleavage fragment [plasma membrane] (R-HSA-2730742) NOTCH1 V1676D S2 cleavage fragment [extracellular region] (R-HSA-2730755) NOTCH1 I1680N Transmembrane Fragment [plasma membrane] (R-HSA-2684869) NOTCH1 I1718T Transmembrane Fragment [plasma membrane] (R-HSA-2684881) NOTCH1 I1616T Extracellular Fragment [extracellular region] (R-HSA-2684866) NOTCH1 L1596H Extracellular Fragment [extracellular region] (R-HSA-2684853) NOTCH1 L1678P Transmembrane Fragment [plasma membrane] (R-HSA-1485591) NOTCH1 A1701P Transmembrane Fragment [plasma membrane] (R-HSA-1485585) NOTCH1 I1616N Extracellular Fragment [extracellular region] (R-HSA-2684862) NOTCH1 L1593P Extracellular Fragment [extracellular region] (R-HSA-1485584) NOTCH1 R1598P Extracellular Fragment [extracellular region] (R-HSA-1485592) NOTCH1 V1576E Extracellular Fragment [extracellular region] (R-HSA-2684852) NOTCH1 V1676D Transmembrane Fragment [plasma membrane] (R-HSA-2684874) NOTCH1 F1592S Extracellular Fragment [extracellular region] (R-HSA-2684847) NOTCH1 L1574Q Extracellular Fragment [extracellular region] (R-HSA-2691203) p-NICD1 Q2440* [nucleoplasm] (R-HSA-2902207) p-NICD1 Q2395* [nucleoplasm] (R-HSA-2902205) p-NICD1 P2514Rfs4 [nucleoplasm] (R-HSA-2159809) p-NICD1 P2474Afs4 [nucleoplasm] (R-HSA-2902204) NOTCH1 L1600P Extracellular Fragment [extracellular region] (R-HSA-2681764) NOTCH1 L1574P Extracellular Fragment [extracellular region] (R-HSA-1485582) NEXT1 P2474Afs4 [plasma membrane] (R-HSA-2902194) NEXT1 Q2395 [plasma membrane] (R-HSA-2902192) NEXT1 Q2440* [plasma membrane] (R-HSA-2902196) NEXT1 P2514Rfs4 [plasma membrane] (R-HSA-2768989) NICD1 Q2395 [cytosol] (R-HSA-2902195) NICD1 P2514Rfs4 [cytosol] (R-HSA-2768996) NICD1 P2474Afs4 [cytosol] (R-HSA-2902193) NICD1 Q2440* [cytosol] (R-HSA-2902191) NICD1 P2514Rfs4 [nucleoplasm] (R-HSA-2769013) NICD1 P2474Afs4 [nucleoplasm] (R-HSA-2902208) NICD1 Q2395* [nucleoplasm] (R-HSA-2902201) NICD1 Q2440* [nucleoplasm] (R-HSA-2902200) NOTCH1 P2514Rfs4 Transmembrane Fragment [plasma membrane] (R-HSA-2768982) NOTCH1 Q2395 Transmembrane Fragment [plasma membrane] (R-HSA-1485596) NOTCH1 Q2440* Transmembrane Fragment [plasma membrane] (R-HSA-1485602) NOTCH1 P2474Afs*4 Transmembrane Fragment [plasma membrane] (R-HSA-2894873) NOTCH1 t(7;9)(NOTCH1:M1580_K2555) extracellular fragment [extracellular region] (R-HSA-2220929) p-NICD1 [nucleoplasm] (R-HSA-1604444) Glc,GlcNAc-Fuc-Pre-NOTCH1 [Golgi membrane] (R-HSA-1911426) Glc,Gal-GlcNAc-Fuc-Pre-NOTCH1 [Golgi membrane] (R-HSA-1911415) Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH1 [Golgi membrane] (R-HSA-1911503) FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) [Golgi membrane] (R-HSA-1911511) Pre-NOTCH1 [endoplasmic reticulum membrane] (R-HSA-157024) 17xFucT-2xFucS-NOTCH1(19-2555) [endoplasmic reticulum membrane] (R-HSA-1467396) 19xFucT-14xGlcS-2xFucS-NOTCH1(19-2555) [endoplasmic reticulum membrane] (R-HSA-1467425) 17xFucT-14xGlcS-2xFucS-NOTCH1(19-2555) [Golgi membrane] (R-HSA-1472872) NOTCH1(1665-2555) [Golgi membrane] (R-HSA-157092) 17xFucT-14xGlcS-2xFucS-NOTCH1(19-1664) [Golgi membrane] (R-HSA-1983679) FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) [plasma membrane] (R-HSA-1911512) NOTCH1(1665-2555) [plasma membrane] (R-HSA-157239) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) [extracellular region] (R-HSA-1983670) NOTCH1(1665-1720) [extracellular region] (R-HSA-157654) NOTCH1(1721-1753) [plasma membrane] (R-HSA-157656) NEXT1 [plasma membrane] (R-HSA-157200) NICD1 [cytosol] (R-HSA-157634) NICD1 [nucleoplasm] (R-HSA-157939)	0.462	7