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p-S69,120-PHF8-1 [nucleoplasm]
Stable Identifier
R-HSA-2245211
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Prophase (Homo sapiens)
Condensation of Prophase Chromosomes (Homo sapiens)
CDK1 phosphorylates PHF8 (Homo sapiens)
p-2S-PHF8:Fe2+ [nucleoplasm] (Homo sapiens)
p-2S-PHF8 [nucleoplasm] (Homo sapiens)
p-S69,120-PHF8-1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UPP1-1 PHF8
Gene Names
PHF8, KIAA1111, ZNF422
Other Identifiers
0004120341
0104560193
11719423_at
11756084_a_at
17111366
212916_at
23133
4009503
4009505
4009507
4009508
4009509
4009510
4009511
4009512
4009513
4009516
4009521
4009522
4009524
4009526
4009527
4009528
4009530
4009531
4009532
4009534
4009536
4009538
4009539
4009540
4009542
4009543
4009544
4009545
4009546
4009547
4009549
4009550
4009552
4009553
4009554
4009555
41399_at
8173009
A_23_P9744
A_24_P130865
A_24_P942253
A_33_P3361925
GO:0000082
GO:0000278
GO:0003674
GO:0003682
GO:0005506
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005635
GO:0005654
GO:0005730
GO:0006325
GO:0006464
GO:0007049
GO:0007420
GO:0008150
GO:0008270
GO:0009058
GO:0016491
GO:0016706
GO:0031965
GO:0032452
GO:0032454
GO:0033169
GO:0034641
GO:0035064
GO:0035574
GO:0035575
GO:0042393
GO:0043167
GO:0043226
GO:0045893
GO:0045943
GO:0046872
GO:0048856
GO:0051213
GO:0051276
GO:0051864
GO:0055114
GO:0061188
GO:0070544
GO:0071557
GO:0071558
Hs.285641.0.S1_3p_at
ILMN_1711318
ILMN_1762169
ILMN_2230530
PH_hs_0022505
TC0X001070.hg
Participant Of
hasCandidate
p-2S-PHF8 [nucleoplasm]
Other forms of this molecule
PHF8-1 [nucleoplasm]
Inferred To
phospho-JHD1 [nucleoplasm] (Saccharomyces cerevisiae)
phospho-ano2 [nucleoplasm] (Xenopus tropicalis)
phospho-jhd1 [nucleoplasm] (Schizosaccharomyces pombe)
phospho-phf8 [nucleoplasm] (Danio rerio)
phospho-WNK3 [nucleoplasm] (Canis familiaris)
phospho-jmjd-1.2 [nucleoplasm] (Caenorhabditis elegans)
Modified Residues
Name
O-phospho-L-serine at 69
Coordinate
69
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 120
Coordinate
120
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
XP_016884851.1
,
NP_055922.1
,
NP_001171826.1
,
NP_001171825.1
OpenTargets
ENSG00000172943
ZINC - Substances
PHF8_HUMAN
ZINC target
Q9UPP1
ZINC - Biogenic
PHF8_HUMAN
PRO
Q9UPP1
PDB
3K3N
,
3K3O
,
3KV4
,
4DO0
,
2WWU
ZINC - Metabolites
PHF8_HUMAN
IntEnz
1.14.11.27
,
1.14.11.65
GeneCards
Q9UPP1
HPA
ENSG00000172943-PHF8
Ensembl
ENSP00000319473
,
ENSP00000350676
,
ENST00000338946
,
ENSP00000338868
,
ENSP00000340051
,
ENSG00000172943
,
ENST00000338154
,
ENST00000322659
,
ENST00000357988
ZINC - Predictions - Purchasable
PHF8_HUMAN
Orphanet
16818
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q06330 RBPJ
1
RBPJ [nucleoplasm]
(R-HSA-3008668)
0.499
2
UniProt:Q01094 E2F1
2
p-E2F1 [nucleoplasm]
(R-HSA-187911)
E2F1 [nucleoplasm]
(R-HSA-68639)
0.499
2
UniProt:P46531 NOTCH1
60
NOTCH1 I1680N S2 cleavage fragment [extracellular region]
(R-HSA-2730744)
NOTCH1 L1678P S2 cleavage fragment [extracellular region]
(R-HSA-2730745)
NOTCH1 I1718T S2 cleavage fragment [extracellular region]
(R-HSA-2730757)
NOTCH1 A1701P S2 cleavage fragment [plasma membrane]
(R-HSA-2730742)
NOTCH1 V1676D S2 cleavage fragment [extracellular region]
(R-HSA-2730755)
NOTCH1 I1680N Transmembrane Fragment [plasma membrane]
(R-HSA-2684869)
NOTCH1 I1718T Transmembrane Fragment [plasma membrane]
(R-HSA-2684881)
NOTCH1 I1616T Extracellular Fragment [extracellular region]
(R-HSA-2684866)
NOTCH1 L1596H Extracellular Fragment [extracellular region]
(R-HSA-2684853)
NOTCH1 L1678P Transmembrane Fragment [plasma membrane]
(R-HSA-1485591)
NOTCH1 A1701P Transmembrane Fragment [plasma membrane]
(R-HSA-1485585)
NOTCH1 I1616N Extracellular Fragment [extracellular region]
(R-HSA-2684862)
NOTCH1 L1593P Extracellular Fragment [extracellular region]
(R-HSA-1485584)
NOTCH1 R1598P Extracellular Fragment [extracellular region]
(R-HSA-1485592)
NOTCH1 V1576E Extracellular Fragment [extracellular region]
(R-HSA-2684852)
NOTCH1 V1676D Transmembrane Fragment [plasma membrane]
(R-HSA-2684874)
NOTCH1 F1592S Extracellular Fragment [extracellular region]
(R-HSA-2684847)
NOTCH1 L1574Q Extracellular Fragment [extracellular region]
(R-HSA-2691203)
p-NICD1 Q2440* [nucleoplasm]
(R-HSA-2902207)
p-NICD1 Q2395* [nucleoplasm]
(R-HSA-2902205)
p-NICD1 P2514Rfs*4 [nucleoplasm]
(R-HSA-2159809)
p-NICD1 P2474Afs*4 [nucleoplasm]
(R-HSA-2902204)
NOTCH1 L1574P Extracellular Fragment [extracellular region]
(R-HSA-1485582)
NOTCH1 L1600P Extracellular Fragment [extracellular region]
(R-HSA-2681764)
NEXT1 P2474Afs*4 [plasma membrane]
(R-HSA-2902194)
NEXT1 Q2395* [plasma membrane]
(R-HSA-2902192)
NEXT1 Q2440* [plasma membrane]
(R-HSA-2902196)
NEXT1 P2514Rfs*4 [plasma membrane]
(R-HSA-2768989)
NICD1 Q2395* [cytosol]
(R-HSA-2902195)
NICD1 P2514Rfs*4 [cytosol]
(R-HSA-2768996)
NICD1 P2474Afs*4 [cytosol]
(R-HSA-2902193)
NICD1 Q2440* [cytosol]
(R-HSA-2902191)
NICD1 P2514Rfs*4 [nucleoplasm]
(R-HSA-2769013)
NICD1 P2474Afs*4 [nucleoplasm]
(R-HSA-2902208)
NICD1 Q2395* [nucleoplasm]
(R-HSA-2902201)
NICD1 Q2440* [nucleoplasm]
(R-HSA-2902200)
NOTCH1 P2514Rfs*4 Transmembrane Fragment [plasma membrane]
(R-HSA-2768982)
NOTCH1 Q2395* Transmembrane Fragment [plasma membrane]
(R-HSA-1485596)
NOTCH1 Q2440* Transmembrane Fragment [plasma membrane]
(R-HSA-1485602)
NOTCH1 P2474Afs*4 Transmembrane Fragment [plasma membrane]
(R-HSA-2894873)
NOTCH1 t(7;9)(NOTCH1:M1580_K2555) extracellular fragment [extracellular region]
(R-HSA-2220929)
p-NICD1 [nucleoplasm]
(R-HSA-1604444)
Glc,GlcNAc-Fuc-Pre-NOTCH1 [Golgi membrane]
(R-HSA-1911426)
Glc,Gal-GlcNAc-Fuc-Pre-NOTCH1 [Golgi membrane]
(R-HSA-1911415)
Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH1 [Golgi membrane]
(R-HSA-1911503)
FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) [Golgi membrane]
(R-HSA-1911511)
Pre-NOTCH1 [endoplasmic reticulum membrane]
(R-HSA-157024)
17xFucT-2xFucS-NOTCH1(19-2555) [endoplasmic reticulum membrane]
(R-HSA-1467396)
19xFucT-14xGlcS-2xFucS-NOTCH1(19-2555) [endoplasmic reticulum membrane]
(R-HSA-1467425)
17xFucT-14xGlcS-2xFucS-NOTCH1(19-2555) [Golgi membrane]
(R-HSA-1472872)
NOTCH1(1665-2555) [Golgi membrane]
(R-HSA-157092)
17xFucT-14xGlcS-2xFucS-NOTCH1(19-1664) [Golgi membrane]
(R-HSA-1983679)
FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) [plasma membrane]
(R-HSA-1911512)
NOTCH1(1665-2555) [plasma membrane]
(R-HSA-157239)
19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) [extracellular region]
(R-HSA-1983670)
NOTCH1(1665-1720) [extracellular region]
(R-HSA-157654)
NOTCH1(1721-1753) [plasma membrane]
(R-HSA-157656)
NEXT1 [plasma membrane]
(R-HSA-157200)
NICD1 [cytosol]
(R-HSA-157634)
NICD1 [nucleoplasm]
(R-HSA-157939)
0.462
7
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