Reactome | p-S69,120-PHF8-1 [nucleoplasm]

p-S69,120-PHF8-1 [nucleoplasm]

Stable Identifier

R-HSA-2245211

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Prophase (Homo sapiens)
      - Condensation of Prophase Chromosomes (Homo sapiens)
        
        CDK1 phosphorylates PHF8 (Homo sapiens)
        
        p-2S-PHF8:Fe2+ [nucleoplasm] (Homo sapiens)
        
        p-2S-PHF8 [nucleoplasm] (Homo sapiens)
        
        p-S69,120-PHF8-1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UPP1-1 PHF8

Gene Names

PHF8, KIAA1111, ZNF422

Other Identifiers

0004120341

0104560193

11719423_at

11756084_a_at

17111366

212916_at

23133

4009503

4009505

4009507

4009508

4009509

4009510

4009511

4009512

4009513

4009516

4009521

4009522

4009524

4009526

4009527

4009528

4009530

4009531

4009532

4009534

4009536

4009538

4009539

4009540

4009542

4009543

4009544

4009545

4009546

4009547

4009549

4009550

4009552

4009553

4009554

4009555

41399_at

8173009

A_23_P9744

A_24_P130865

A_24_P942253

A_33_P3361925

GO:0000082

GO:0000278

GO:0003674

GO:0003682

GO:0005506

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005635

GO:0005654

GO:0005730

GO:0006325

GO:0006464

GO:0007049

GO:0007420

GO:0008150

GO:0008270

GO:0009058

GO:0016491

GO:0016706

GO:0031965

GO:0032452

GO:0032454

GO:0033169

GO:0034641

GO:0035064

GO:0035574

GO:0035575

GO:0042393

GO:0043167

GO:0043226

GO:0045893

GO:0045943

GO:0046872

GO:0048856

GO:0051213

GO:0051276

GO:0051864

GO:0055114

GO:0061188

GO:0070544

GO:0071557

GO:0071558

Hs.285641.0.S1_3p_at

ILMN_1711318

ILMN_1762169

ILMN_2230530

PH_hs_0022505

TC0X001070.hg

Participant Of

hasCandidate

p-2S-PHF8 [nucleoplasm]

Other forms of this molecule

PHF8-1 [nucleoplasm]

Inferred To

phospho-JHD1 [nucleoplasm] (Saccharomyces cerevisiae)

phospho-ano2 [nucleoplasm] (Xenopus tropicalis)

phospho-jhd1 [nucleoplasm] (Schizosaccharomyces pombe)

phospho-phf8 [nucleoplasm] (Danio rerio)

phospho-WNK3 [nucleoplasm] (Canis familiaris)

phospho-jmjd-1.2 [nucleoplasm] (Caenorhabditis elegans)

Modified Residues

Name

O-phospho-L-serine at 69

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 120

Coordinate

120

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

XP_016884851.1, NP_055922.1, NP_001171826.1, NP_001171825.1

OpenTargets

ENSG00000172943

ZINC - Substances

PHF8_HUMAN

ZINC target

Q9UPP1

ZINC - Biogenic

PHF8_HUMAN

PRO

Q9UPP1

PDB

3K3N, 3K3O, 3KV4, 4DO0, 2WWU

ZINC - Metabolites

PHF8_HUMAN

IntEnz

1.14.11.27, 1.14.11.65

GeneCards

Q9UPP1

HPA

ENSG00000172943-PHF8

Ensembl

ENSP00000319473, ENSP00000350676, ENST00000338946, ENSP00000338868, ENSP00000340051, ENSG00000172943, ENST00000338154, ENST00000322659, ENST00000357988

ZINC - Predictions - Purchasable

PHF8_HUMAN

Orphanet

16818

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q06330 RBPJ	1	RBPJ [nucleoplasm] (R-HSA-3008668)	0.499	2
UniProt:Q01094 E2F1	2	p-E2F1 [nucleoplasm] (R-HSA-187911) E2F1 [nucleoplasm] (R-HSA-68639)	0.499	2
UniProt:P46531 NOTCH1	60	NOTCH1 I1680N S2 cleavage fragment [extracellular region] (R-HSA-2730744) NOTCH1 L1678P S2 cleavage fragment [extracellular region] (R-HSA-2730745) NOTCH1 I1718T S2 cleavage fragment [extracellular region] (R-HSA-2730757) NOTCH1 A1701P S2 cleavage fragment [plasma membrane] (R-HSA-2730742) NOTCH1 V1676D S2 cleavage fragment [extracellular region] (R-HSA-2730755) NOTCH1 I1680N Transmembrane Fragment [plasma membrane] (R-HSA-2684869) NOTCH1 I1718T Transmembrane Fragment [plasma membrane] (R-HSA-2684881) NOTCH1 I1616T Extracellular Fragment [extracellular region] (R-HSA-2684866) NOTCH1 L1596H Extracellular Fragment [extracellular region] (R-HSA-2684853) NOTCH1 L1678P Transmembrane Fragment [plasma membrane] (R-HSA-1485591) NOTCH1 A1701P Transmembrane Fragment [plasma membrane] (R-HSA-1485585) NOTCH1 I1616N Extracellular Fragment [extracellular region] (R-HSA-2684862) NOTCH1 L1593P Extracellular Fragment [extracellular region] (R-HSA-1485584) NOTCH1 R1598P Extracellular Fragment [extracellular region] (R-HSA-1485592) NOTCH1 V1576E Extracellular Fragment [extracellular region] (R-HSA-2684852) NOTCH1 V1676D Transmembrane Fragment [plasma membrane] (R-HSA-2684874) NOTCH1 F1592S Extracellular Fragment [extracellular region] (R-HSA-2684847) NOTCH1 L1574Q Extracellular Fragment [extracellular region] (R-HSA-2691203) p-NICD1 Q2440* [nucleoplasm] (R-HSA-2902207) p-NICD1 Q2395* [nucleoplasm] (R-HSA-2902205) p-NICD1 P2514Rfs4 [nucleoplasm] (R-HSA-2159809) p-NICD1 P2474Afs4 [nucleoplasm] (R-HSA-2902204) NOTCH1 L1574P Extracellular Fragment [extracellular region] (R-HSA-1485582) NOTCH1 L1600P Extracellular Fragment [extracellular region] (R-HSA-2681764) NEXT1 P2474Afs4 [plasma membrane] (R-HSA-2902194) NEXT1 Q2395 [plasma membrane] (R-HSA-2902192) NEXT1 Q2440* [plasma membrane] (R-HSA-2902196) NEXT1 P2514Rfs4 [plasma membrane] (R-HSA-2768989) NICD1 Q2395 [cytosol] (R-HSA-2902195) NICD1 P2514Rfs4 [cytosol] (R-HSA-2768996) NICD1 P2474Afs4 [cytosol] (R-HSA-2902193) NICD1 Q2440* [cytosol] (R-HSA-2902191) NICD1 P2514Rfs4 [nucleoplasm] (R-HSA-2769013) NICD1 P2474Afs4 [nucleoplasm] (R-HSA-2902208) NICD1 Q2395* [nucleoplasm] (R-HSA-2902201) NICD1 Q2440* [nucleoplasm] (R-HSA-2902200) NOTCH1 P2514Rfs4 Transmembrane Fragment [plasma membrane] (R-HSA-2768982) NOTCH1 Q2395 Transmembrane Fragment [plasma membrane] (R-HSA-1485596) NOTCH1 Q2440* Transmembrane Fragment [plasma membrane] (R-HSA-1485602) NOTCH1 P2474Afs*4 Transmembrane Fragment [plasma membrane] (R-HSA-2894873) NOTCH1 t(7;9)(NOTCH1:M1580_K2555) extracellular fragment [extracellular region] (R-HSA-2220929) p-NICD1 [nucleoplasm] (R-HSA-1604444) Glc,GlcNAc-Fuc-Pre-NOTCH1 [Golgi membrane] (R-HSA-1911426) Glc,Gal-GlcNAc-Fuc-Pre-NOTCH1 [Golgi membrane] (R-HSA-1911415) Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH1 [Golgi membrane] (R-HSA-1911503) FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) [Golgi membrane] (R-HSA-1911511) Pre-NOTCH1 [endoplasmic reticulum membrane] (R-HSA-157024) 17xFucT-2xFucS-NOTCH1(19-2555) [endoplasmic reticulum membrane] (R-HSA-1467396) 19xFucT-14xGlcS-2xFucS-NOTCH1(19-2555) [endoplasmic reticulum membrane] (R-HSA-1467425) 17xFucT-14xGlcS-2xFucS-NOTCH1(19-2555) [Golgi membrane] (R-HSA-1472872) NOTCH1(1665-2555) [Golgi membrane] (R-HSA-157092) 17xFucT-14xGlcS-2xFucS-NOTCH1(19-1664) [Golgi membrane] (R-HSA-1983679) FRINGE-modified NOTCH1 Extracellular Fragment (NECD1) [plasma membrane] (R-HSA-1911512) NOTCH1(1665-2555) [plasma membrane] (R-HSA-157239) 19xFucT-16xGlcS-2xFucS-NOTCH1(19-1664) [extracellular region] (R-HSA-1983670) NOTCH1(1665-1720) [extracellular region] (R-HSA-157654) NOTCH1(1721-1753) [plasma membrane] (R-HSA-157656) NEXT1 [plasma membrane] (R-HSA-157200) NICD1 [cytosol] (R-HSA-157634) NICD1 [nucleoplasm] (R-HSA-157939)	0.462	7

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