Reactome | p-S69,120-PHF8-1 [nucleoplasm]

p-S69,120-PHF8-1 [nucleoplasm]

Stable Identifier

R-HSA-2245211

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Prophase (Homo sapiens)
      - Condensation of Prophase Chromosomes (Homo sapiens)
        
        CDK1 phosphorylates PHF8 (Homo sapiens)
        
        p-2S-PHF8:Fe2+ [nucleoplasm] (Homo sapiens)
        
        p-2S-PHF8 [nucleoplasm] (Homo sapiens)
        
        p-S69,120-PHF8-1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UPP1-1 PHF8

Gene Names

PHF8, KIAA1111, ZNF422

Participates

as a candidate of

p-2S-PHF8 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

PHF8-1 [nucleoplasm]

Inferred To

phospho-jhd1 [nucleoplasm] (Schizosaccharomyces pombe)

phospho-phf8 [nucleoplasm] (Danio rerio)

phospho-PHF8 [nucleoplasm] (Bos taurus)

Modified Residues

Name

O-phospho-L-serine at 69

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 120

Coordinate

120

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_001171826.1, XP_054182696.1, XP_047297890.1, NP_055922.1, NP_001171827.1, XP_016884851.1, NP_001171825.1

Guide to Pharmacology - Targets

2698

OpenTargets

ENSG00000172943

ENSEMBL

ENSP00000338868, ENSG00000172943, ENST00000357988, ENSP00000350676, ENST00000322659, ENST00000338154, ENSP00000319473

ZINC - Substances

PHF8_HUMAN

ZINC - Biogenic

PHF8_HUMAN

ZINC target

Q9UPP1

PRO

Q9UPP1

GlyGen

Q9UPP1

PDB

7CMZ, 3K3O, 3K3N, 2WWU, 3KV4, 4DO0

ZINC - Metabolites

PHF8_HUMAN

HPA

ENSG00000172943-PHF8

GeneCards

PHF8

Pharos - Targets

Q9UPP1

Orphanet

PHF8

ZINC - Predictions - Purchasable

PHF8_HUMAN

HMDB Protein

HMDBP11880

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y462 ZNF711	1	ZNF711 [nucleoplasm] (R-HSA-2454159)	0.69	7
UniProt:Q15013 MD2BP			0.527	3
UniProt:P20248 CCNA2	5	p-S154-CCNA2 [nucleoplasm] (R-HSA-9929512) p-S154-CCNA2 [cytosol] (R-HSA-9929551) CCNA2 [nucleoplasm] (R-HSA-68905) CCNA2 [cytosol] (R-HSA-157444) PolyUb-CCNA2 [nucleoplasm] (R-HSA-6783099)	0.527	3
UniProt:Q16778 H2BC21	9	HIST2H2BE [nucleoplasm] (R-HSA-181908) Ub-121-HIST2H2BE [nucleoplasm] (R-HSA-3364018) AcK16-HIST2H2BE [nucleoplasm] (R-HSA-4568660) AcK6-HIST2H2BE [nucleoplasm] (R-HSA-4568679) AcK21-HIST2H2BE [nucleoplasm] (R-HSA-4568716) AcK13-HIST2H2BE [nucleoplasm] (R-HSA-4568651) HIST2H2BE [extracellular region] (R-HSA-977571) Ack-HIST2H2BE [nucleoplasm] (R-HSA-4549257) Ub-HIST2H2BE [nucleoplasm] (R-HSA-6782539)	0.527	2
UniProt:P10619 CTSA	7	CTSA(327-480) [lysosomal lumen] (R-HSA-1605642) CTSA(29-326) [lysosomal lumen] (R-HSA-1605735) CTSA(327-480) [azurophil granule lumen] (R-HSA-6799120) CTSA(29-326) [azurophil granule lumen] (R-HSA-6799135) CTSA(327-480) [extracellular region] (R-HSA-6806233) CTSA(29-326) [extracellular region] (R-HSA-6806187) CTSA(29-480) [lysosomal lumen] (R-HSA-1181230)	0.527	2
UniProt:P43363 MAGAA			0.527	2
UniProt:Q5SXM2 SNAPC4	1	SNAPC4 [nucleoplasm] (R-HSA-83729)	0.527	3
UniProt:Q9NRW3 APOBEC3C	1	APOBEC3C [nucleoplasm] (R-HSA-8874997)	0.527	2
UniProt:Q01433 AMPD2	1	AMPD2 [cytosol] (R-HSA-49927)	0.527	3
UniProt:P16278 GLB1	8	GLB1 [lysosomal lumen] (R-HSA-1605623) GLB1 [ficolin-1-rich granule lumen] (R-HSA-6800968) GLB1 [extracellular region] (R-HSA-6806213) GLB1 [azurophil granule lumen] (R-HSA-6799124) GLB1 W273L [lysosomal lumen] (R-HSA-2262738) GLB1 R482C [lysosomal lumen] (R-HSA-2262739) GLB1 Y83C [lysosomal lumen] (R-HSA-2262735) GLB1 W509C [lysosomal lumen] (R-HSA-2262732)	0.527	2
UniProt:Q96QS3 ARX			0.524	3
UniProt:Q06330 RBPJ	1	RBPJ [nucleoplasm] (R-HSA-3008668)	0.499	2
UniProt:Q01094 E2F1	2	E2F1 [nucleoplasm] (R-HSA-68639) p-E2F1 [nucleoplasm] (R-HSA-187911)	0.499	2
UniProt:P46531 NOTCH1	20	NOTCH1 L1678P S2 cleavage fragment [extracellular region] (R-HSA-2730745) NOTCH1 I1680N S2 cleavage fragment [extracellular region] (R-HSA-2730744) NOTCH1 I1718T S2 cleavage fragment [extracellular region] (R-HSA-2730757) NOTCH1 A1701P S2 cleavage fragment [plasma membrane] (R-HSA-2730742) NOTCH1 V1676D S2 cleavage fragment [extracellular region] (R-HSA-2730755) NOTCH1 I1680N Transmembrane Fragment [plasma membrane] (R-HSA-2684869) NOTCH1 I1718T Transmembrane Fragment [plasma membrane] (R-HSA-2684881) NOTCH1 I1616T Extracellular Fragment [extracellular region] (R-HSA-2684866) NOTCH1 L1596H Extracellular Fragment [extracellular region] (R-HSA-2684853) NOTCH1 L1678P Transmembrane Fragment [plasma membrane] (R-HSA-1485591) NOTCH1 A1701P Transmembrane Fragment [plasma membrane] (R-HSA-1485585) NOTCH1 I1616N Extracellular Fragment [extracellular region] (R-HSA-2684862) NOTCH1 L1593P Extracellular Fragment [extracellular region] (R-HSA-1485584) NOTCH1 R1598P Extracellular Fragment [extracellular region] (R-HSA-1485592) NOTCH1 V1576E Extracellular Fragment [extracellular region] (R-HSA-2684852) NOTCH1 V1676D Transmembrane Fragment [plasma membrane] (R-HSA-2684874) NOTCH1 F1592S Extracellular Fragment [extracellular region] (R-HSA-2684847) NOTCH1 L1574Q Extracellular Fragment [extracellular region] (R-HSA-2691203) p-NICD1 Q2440* [nucleoplasm] (R-HSA-2902207) p-NICD1 Q2395* [nucleoplasm] (R-HSA-2902205)	0.462	7

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