Reactome | SPARC [endocytic vesicle lumen]

SPARC [endocytic vesicle lumen]

Stable Identifier

R-HSA-2239456

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endocytic vesicle lumen

Synonyms

Osteonectin

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Binding and Uptake of Ligands by Scavenger Receptors (Homo sapiens)
  - Scavenging by Class H Receptors (Homo sapiens)
    - STAB1:ligand is endocytosed (Homo sapiens)
      - STAB1:Ligand [endocytic vesicle membrane] (Homo sapiens)
        
        Ligands of STAB1 [endocytic vesicle lumen] (Homo sapiens)
        
        SPARC [endocytic vesicle lumen] (Homo sapiens)

External Reference Information

External Reference

UniProt:P09486 SPARC

Gene Names

SPARC, ON

Chain

signal peptide:1-17, chain:18-303

Reference Genes

BioGPS Gene:6678 SPARC

COSMIC (genes):SPARC SPARC

CTD Gene:6678 SPARC

dbSNP Gene:6678 SPARC

ENSEMBL:ENSG00000113140 SPARC

ENSEMBL_homo_sapiens_GENE:ENSG00000113140.11 SPARC

HGNC:11219 SPARC

KEGG Gene (Homo sapiens):6678 SPARC

Monarch:6678 SPARC

NCBI Gene:6678 SPARC

OMIM:182120 SPARC

UCSC:P09486 SPARC

Reference Transcript

Other Identifiers

11715602_s_at

11715603_s_at

11715604_x_at

11746554_a_at

11746555_x_at

11754058_a_at

11754059_x_at

11763872_x_at

17001927

200665_PM_s_at

200665_s_at

212667_PM_at

212667_at

2882114

2882115

2882116

2882117

2882118

2882119

2882120

2882121

2882122

2882123

2882124

2882125

2882126

2882128

2882131

2882133

2882137

2882138

2882139

2882142

2882143

2882145

2882155

2882156

6678

671_at

73433_at

73938_at

7896722

8115327

A_23_P7642

A_33_P3382924

GE545368

GE845355

GO:0001937

GO:0005198

GO:0005201

GO:0005509

GO:0005515

GO:0005518

GO:0005576

GO:0005604

GO:0005615

GO:0005634

GO:0005737

GO:0005886

GO:0009986

GO:0010595

GO:0016363

GO:0016525

GO:0022604

GO:0030312

GO:0031012

GO:0031091

GO:0031092

GO:0031093

GO:0031410

GO:0043226

GO:0043231

GO:0046872

GO:0048856

GO:0048870

GO:0050840

GO:0062023

GO:0071682

HMNXSV003019558

Hs.111779.1.S1_3p_at

ILMN_1796734

J03040_at

TC05001955.hg

TC05003313.hg

g4507170_3p_a_at

Participates

as a member of

Ligands of STAB1 [endocytic vesicle lumen] (Homo sapiens)

Other forms of this molecule

SPARC [platelet alpha granule lumen]

SPARC [plasma membrane]

SPARC [extracellular region]

Inferred To

sparc [endocytic vesicle lumen] (Danio rerio)

Homologues of SPARC [endocytic vesicle lumen] (Sus scrofa)

SPARC [endocytic vesicle lumen] (Bos taurus)

SPARC [endocytic vesicle lumen] (Canis familiaris)

SPARC [endocytic vesicle lumen] (Gallus gallus)

SPARC [endocytic vesicle lumen] (Mus musculus)

SPARC [endocytic vesicle lumen] (Rattus norvegicus)

SPARC [endocytic vesicle lumen] (Sus scrofa)

Cross References

RefSeq

NP_003109.1, NP_001296372.1, NP_001296373.1

OpenTargets

ENSG00000113140

GeneCards

P09486

HPA

ENSG00000113140-SPARC

Ensembl

ENSG00000113140, ENST00000231061, ENSP00000231061

PRO

P09486

Pharos - Targets

P09486

Orphanet

23287

HMDB Protein

HMDBP02109

PDB

1NUB, 1SRA, 2V53, 1BMO

Interactors (3)

Accession	Confidence Score	Evidence (IntAct)
UniProt:Q2TV77 Q2TV77	0.598	4
UniProt:P02461-1 COL3A1	0.558	4
UniProt:Q99972 MYOC	0.527	3