LRP1:Hemopexin:heme is endocytosed

Stable Identifier
R-HSA-2230983
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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The LRP1:hemopexin:heme complex is endocytosed and the complex is dissociated in lysosomes, leading to heme uptake. Heme is then degraded by heme oxygenases. Whereas LRP1 is subsequently recycled to the plasma membrane, the destiny of hemopexin is controversial. Some studies have suggested that hemopexin can be recycled as an intact molecule to the extracellular milieu (Smith and Morgan, 1979). However, it has also been proposed that following hepatic uptake of heme from hemopexin:heme, varying proportions of the protein are either returned to the circulation or degraded in the liver (Potter et al., 1993). Recently, Hvidberg et al. have shown that most hemopexin is degraded in lysosomes (Hvidberg et al., 2005).

Literature References
PubMed ID Title Journal Year
496916 Haem transport to the liver by haemopexin. Receptor-mediated uptake with recycling of the protein

Smith, A, Morgan, WT

Biochem. J. 1979
15947085 Identification of the receptor scavenging hemopexin-heme complexes

Hvidberg, V, Maniecki, MB, Jacobsen, C, Højrup, P, Møller, HJ, Moestrup, SK

Blood 2005
8424694 In vivo fate of hemopexin and heme-hemopexin complexes in the rat

Potter, D, Chroneos, ZC, Baynes, JW, Sinclair, PR, Gorman, N, Liem, HH, Muller-Eberhard, U, Thorpe, SR

Arch. Biochem. Biophys. 1993
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