Hemoglobin:Haptoglobin:CD163 is endocytosed

Stable Identifier
Reaction [omitted]
Homo sapiens
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The CD163:haptoglobin:hemoglobin complex is endocytosed (Schaer et al. 2006, Kristiansen et al. 2001) by monocytes or macrophages. CD163 is constitutively endocytosed by monocytes independently of ligand binding (Schaer et al. 2006). Upon endocytosis, the receptor–ligand complex enters early endosomes where haptoglobin:hemoglobin complexes are released from CD163. The receptor then recycles to the cell surface while haptoglobin:hemoglobin complexes continue through the endocytic pathway to end up in lysosomes where the protein moieties and the ligand are degraded.

Literature References
PubMed ID Title Journal Year
17008602 Constitutive endocytosis of CD163 mediates hemoglobin-heme uptake and determines the noninflammatory and protective transcriptional response of macrophages to hemoglobin

Schoedon, G, Imhof, A, Kurrer, MO, Schaer, DJ, Schaer, CA

Circ. Res. 2006
16189277 CD163 is the macrophage scavenger receptor for native and chemically modified hemoglobins in the absence of haptoglobin

Boykins, RA, Schaer, CA, Alayash, AI, Schaer, DJ, Schaffner, A, Buehler, PW, Schoedon, G

Blood 2006
11196644 Identification of the haemoglobin scavenger receptor

Hoffman, HJ, Sonne, O, Kristiansen, M, Moestrup, SK, Jacobsen, C, Law, SK, Graversen, JH

Nature 2001
Orthologous Events
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