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COL18A1(1572-11754) [extracellular region]
Stable Identifier
R-HSA-2225575
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Endostatin, Endostatin-XVIII, COL18A1
Locations in the PathwayBrowser for interactor ChEBI:28304 HEPARIN
Expand all
Extracellular matrix organization (Homo sapiens)
Collagen formation (Homo sapiens)
Assembly of collagen fibrils and other multimeric structures (Homo sapiens)
Release of endostatin-like peptides (Homo sapiens)
COL18A1(1572-11754) [extracellular region] (Homo sapiens)
Degradation of the extracellular matrix (Homo sapiens)
Activation of Matrix Metalloproteinases (Homo sapiens)
Activation of proMMP9 by proteases (Homo sapiens)
COL18A1(1572-11754) [extracellular region] (Homo sapiens)
Autocatalytic activation of proMMP13 (Homo sapiens)
COL18A1(1572-11754) [extracellular region] (Homo sapiens)
Autocatalytic activation of proMMP2 (Homo sapiens)
COL18A1(1572-11754) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P39060 COL18A1
Gene Names
COL18A1
Chain
signal peptide:1-23, chain:24-1754, chain:1572-1754, chain:-1754
Reference Genes
BioGPS Gene:80781 COL18A1
COSMIC (genes):COL18A1 COL18A1
CTD Gene:80781 COL18A1
dbSNP Gene:80781 COL18A1
ENSEMBL:ENSG00000182871 COL18A1
HGNC:2195 COL18A1
KEGG:hsa:80781 COL18A1
Monarch:80781 COL18A1
NCBI Gene:80781 COL18A1
OMIM:120328 COL18A1
UCSC:P39060 COL18A1
Reference Transcript
RefSeq:NM_030582.3 COL18A1
RefSeq:NM_130445.3 COL18A1
RefSeq:NM_001379500.1 COL18A1
RefSeq:NM_130444.2 COL18A1
Participates
as an output of
Release of endostatin-like peptides (Homo sapiens)
as a component of
Endostatin dimer [extracellular region] (Homo sapiens)
This entity regulates
Negatively
Autocatalytic activation of proMMP2
(Homo sapiens)
Activation of proMMP9 by proteases
(Homo sapiens)
Autocatalytic activation of proMMP13
(Homo sapiens)
Other forms of this molecule
GalHyl-COL18A1(24-1754) [endoplasmic reticulum lumen]
3x4Hyp-3Hyp-GalHyl-COL18A1(24-1754) [endoplasmic reticulum lumen]
3x4Hyp-GlcGalHyl-COL18A1(24-1754) [endoplasmic reticulum lumen]
3x4Hyp-GalHyl-COL18A1(24-1754) [endoplasmic reticulum lumen]
3x4Hyp-3Hyp-GlcGalHyl-COL18A1(24-1754) [endoplasmic reticulum lumen]
GlcGalHyl-COL18A1(24-1754) [endoplasmic reticulum lumen]
COL18A1(24-1754) [endoplasmic reticulum lumen]
3x4Hyp-COL18A1(24-1754) [endoplasmic reticulum lumen]
3x4Hyp-3Hyp-COL18A1(24-1754) [endoplasmic reticulum lumen]
5Hyl-COL18A1(?-1754) [extracellular region]
3x4Hyp-3Hyp-5Hyl-COL18A1(?-1754) [extracellular region]
3x4Hyp-5Hyl-COL18A1(?-1754) [extracellular region]
3x4Hyp-GalHyl-COL18A1(?-1754) [extracellular region]
GalHyl-COL18A1(?-1754) [extracellular region]
3x4Hyp-3Hyp-GlcGalHyl-COL18A1(?-1754) [extracellular region]
3x4Hyp-3Hyp-COL18A1(?-1754) [extracellular region]
3x4Hyp-3Hyp-GalHyl-COL18A1(?-1754) [extracellular region]
3x4Hyp-COL18A1(?-1754) [extracellular region]
GlcGalHyl-COL18A1(?-1754) [extracellular region]
3x4Hyp-GlcGalHyl-COL18A1(?-1754) [extracellular region]
COL18A1(?-1754) [extracellular region]
3x4Hyp-5Hyl-COL18A1(24-1754) [extracellular region]
3x4Hyp-GalHyl-COL18A1(24-1754) [extracellular region]
COL18A1(24-1754) [extracellular region]
3x4Hyp-3Hyp-COL18A1(24-1754) [extracellular region]
3x4Hyp-GlcGalHyl-COL18A1(24-1754) [extracellular region]
3x4Hyp-3Hyp-GalHyl-COL18A1(24-1754) [extracellular region]
3x4Hyp-3Hyp-GlcGalHyl-COL18A1(24-1754) [extracellular region]
GalHyl-COL18A1(24-1754) [extracellular region]
5Hyl-COL18A1(24-1754) [extracellular region]
3x4Hyp-COL18A1(24-1754) [extracellular region]
GlcGalHyl-COL18A1(24-1754) [extracellular region]
3x4Hyp-3Hyp-5Hyl-COL18A1(24-1754) [extracellular region]
3x4Hyp-GlcGalHyl-COL18A1(24-?) [extracellular region]
3x4Hyp-GalHyl-COL18A1(24-?) [extracellular region]
5Hyl-COL18A1(24-?) [extracellular region]
3x4Hyp-5Hyl-COL18A1(24-?) [extracellular region]
3x4Hyp-3Hyp-COL18A1(24-?) [extracellular region]
GlcGalHyl-COL18A1(24-?) [extracellular region]
3x4Hyp-3Hyp-GlcGalHyl-COL18A1(24-?) [extracellular region]
GalHyl-COL18A1(24-?) [extracellular region]
3x4Hyp-COL18A1(24-?) [extracellular region]
COL18A1(24-?) [extracellular region]
3x4Hyp-3Hyp-GalHyl-COL18A1(24-?) [extracellular region]
3x4Hyp-3Hyp-5Hyl-COL18A1(24-?) [extracellular region]
COL18A1(?-1571) [extracellular region]
5Hyl-COL18A1(24-1754) [endoplasmic reticulum lumen]
3x4Hyp-3Hyp-5Hyl-COL18A1(24-1754) [endoplasmic reticulum lumen]
3x4Hyp-5Hyl-COL18A1(24-1754) [endoplasmic reticulum lumen]
Inferred To
Col18a1 [extracellular region]
(Mus musculus)
Col18a1 [extracellular region]
(Rattus norvegicus)
Homologues of COL18A1(1572-11754) [extracellular region]
(Caenorhabditis elegans)
col-99 [extracellular region]
(Caenorhabditis elegans)
Mp [extracellular region]
(Drosophila melanogaster)
COL18A1 [extracellular region]
(Bos taurus)
COL18A1 [extracellular region]
(Canis familiaris)
COL18A1 [extracellular region]
(Gallus gallus)
COL18A1 [extracellular region]
(Sus scrofa)
col-115 [extracellular region]
(Caenorhabditis elegans)
emid1 [extracellular region]
(Xenopus tropicalis)
let-2 [extracellular region]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_001366429.1
,
NP_569712.2
,
NP_085059.2
,
NP_569711.2
OpenTargets
ENSG00000182871
ENSEMBL
ENSP00000347665
,
ENST00000355480
,
ENSP00000352798
,
ENST00000651438
,
ENSG00000182871
,
ENST00000359759
,
ENSP00000498485
GeneCards
COL18A1
HPA
ENSG00000182871-COL18A1
PRO
P39060
Pharos - Targets
P39060
GlyGen
P39060
Orphanet
COL18A1
HMDB Protein
HMDBP13479
PDB
1BNL
,
3HON
,
3HSH
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
ChEBI:28304 HEPARIN
0.564
2
UniProt:P08253 MMP2
5
MMP2(110-660) [extracellular region]
(R-HSA-381456)
MMP2(30-660) [extracellular region]
(R-HSA-1604364)
MMP2(67-660) [extracellular region]
(R-HSA-1604345)
MMP2(30-66) [extracellular region]
(R-HSA-1604347)
MMP2(67-109) [extracellular region]
(R-HSA-1604371)
0.527
2
UniProt:O60568 PLOD3
1
PLOD3 [endoplasmic reticulum membrane]
(R-HSA-1981135)
0.527
4
UniProt:O15460 P4HA2
1
P4HA2 [endoplasmic reticulum lumen]
(R-HSA-2980974)
0.527
3
UniProt:Q6ISS4 LAIR2
1
LAIR2 [extracellular region]
(R-HSA-5696342)
0.527
3
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