NOTCH1 PEST domain mutants stimulate HEY transcription

Stable Identifier
Reaction [omitted]
Homo sapiens
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NICD1 PEST domain mutants are expected to stimulate transcription of HEY genes (HEY1, HEY2 and HEYL) in a similar manner to wild-type NICD1 (Fischer et al. 2004, Leimeister et al. 2000, Maier et al. 2000, Arnett et al. 2010).

Literature References
PubMed ID Title Journal Year
11044625 Analysis of HeyL expression in wild-type and Notch pathway mutant mouse embryos

Gessler, M, Schumacher, N, Steidl, C, Leimeister, C

Mech Dev 2000
20972443 Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes

McArthur, DG, Kopan, R, Blacklow, SC, Arnett, KL, Hass, M, Aster, JC, Ilagan, MXG

Nat Struct Mol Biol 2010
10964718 Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes

Gessler, M, Maier, MM

Biochem Biophys Res Commun 2000
15107403 The Notch target genes Hey1 and Hey2 are required for embryonic vascular development

Gessler, M, Schumacher, N, Maier, M, Sendtner, M, Fischer, A

Genes Dev 2004
This event is regulated
Normal reaction
Functional status

Gain of function of NOTCH1 PEST Domain Mutants Coactivator Complex:HEY Genes [nucleoplasm]

Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
T-cell leukemia DOID:715
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