NOTCH1 PEST domain mutants stimulate HEY transcription

Stable Identifier
R-HSA-2220981
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NOTCH1 PEST domain mutants stimulate HEY transcription
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NICD1 PEST domain mutants are expected to stimulate transcription of HEY genes (HEY1, HEY2 and HEYL) in a similar manner to wild-type NICD1 (Fischer et al. 2004, Leimeister et al. 2000, Maier et al. 2000, Arnett et al. 2010).
Literature References
PubMed ID Title Journal Year
11044625 Analysis of HeyL expression in wild-type and Notch pathway mutant mouse embryos

Leimeister, C, Schumacher, N, Steidl, C, Gessler, M

Mech Dev 2000
20972443 Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes

Arnett, KL, Hass, M, McArthur, DG, Ilagan, MXG, Aster, JC, Kopan, R, Blacklow, SC

Nat Struct Mol Biol 2010
10964718 Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes

Maier, MM, Gessler, M

Biochem Biophys Res Commun 2000
15107403 The Notch target genes Hey1 and Hey2 are required for embryonic vascular development

Fischer, A, Schumacher, N, Maier, M, Sendtner, M, Gessler, M

Genes Dev 2004
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
NOTCH1 PEST Domain Mutants Coactivator Complex:HEY Genes [nucleoplasm] (Homo sapiens)
Normal reaction
NOTCH1 stimulates HEY transcription (Homo sapiens)
Functional status

Gain of function of NOTCH1 PEST Domain Mutants Coactivator Complex:HEY Genes [nucleoplasm]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
T-cell acute lymphoblastic leukemia DOID:5603
Cross References
Mondo
Authored
Orlic-Milacic, M  (2013-01-04)
Reviewed
Haw, R  (2013-02-10)
Created
Orlic-Milacic, M  (2012-05-03)
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