NOTCH1 PEST domain mutants coactivator complex binds CDK8:CCNC

Stable Identifier
R-HSA-2220957
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NOTCH1 PEST domain mutants coactivator complex binds CDK8:CCNC
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
MAML is expected to recruit CDK8 to NICD1 PEST domain mutants like it recruits CDK8 to wild-type NICD1 (Fryer et al. 2004).
Literature References
PubMed ID Title Journal Year
15546612 Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover

Fryer, CJ, Jones, KA, White, JB

Mol Cell 2004
Participants
Input
Output
Participates
as an event of
Normal reaction
MAML in complex with NICD1 recruits CDK8 (Homo sapiens)
Functional status

Gain of function of NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
T-cell acute lymphoblastic leukemia DOID:5603
Authored
Orlic-Milacic, M  (2013-01-04)
Reviewed
Haw, R  (2013-02-10)
Created
Orlic-Milacic, M  (2012-05-03)
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