After NOTCH1 PEST domain mutants bind a DLL (DLL1 or DLL4) or JAG ligand (JAG1 or JAG2) in trans, they are expected to be cleaved by ADAM10 or ADAM17 metalloproteases, like the wild-type ligand-bound NOTCH1, to produce NEXT1 PEST domain mutant fragments (Pan and Rubin 1997, Brou et al. 2000, Hartmann et al. 2002, Gordon et al. 2007, van Tetering et al. 2009).
Hartmann, D, De Strooper, B, Herreman, A, Lena Illert, A, Saftig, P, Lübke, T, von Figura, K, Craessaerts, K, Umans, L, Annaert, W, Serneels, L
Pan, D, Rubin, GM
Bessia, C, Black, RA, Roux, P, LeBail, O, Doedens, JR, Gupta, N, Brou, C, Israel, A, Logeat, F, Cumano, A
Blacklow, SC, Vardar-Ulu, D, Sanchez-Irizarry, C, Aster, JC, Gordon, WR, Histen, G
Kopan, R, Verlaan, I, van Tetering, G, van der Wall, E, Vooijs, M, van Diest, P
metallopeptidase activity of ADAM10/17:Zn2+ [plasma membrane]
Gain of function of Ub-DLL/JAG:NOTCH1 PEST Domain Mutants [plasma membrane]
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