Cleavage of collagen VII NC2 region by BMP1

Stable Identifier
R-HSA-2214330
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Bone morphogenetic protein-1 (BMP1) cleaves the C-terminal propeptide from human procollagen VII within the NC2 domain at the BMP1 consensus cleavage site SYAA|DTAG. Mammalian tolloid-like (mTLL)-1 and -2 can substitute for BMP1 (Ratttenholl et al. 2002).

Literature References
PubMed ID Title Journal Year
11986329 Proteinases of the bone morphogenetic protein-1 family convert procollagen VII to mature anchoring fibril collagen

Rattenholl, A, Pappano, WN, Koch, M, Keene, DR, Kadler, KE, Sasaki, T, Timpl, R, Burgeson, RE, Greenspan, DS, Bruckner-Tuderman, L

J Biol Chem 2002
Participants
Participates
Catalyst Activity

serine-type endopeptidase activity of Collagen type VII NC2 proteinases [extracellular region]

Orthologous Events
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