Bone morphogenetic protein-1 (BMP1) cleaves the C-terminal propeptide from human procollagen VII within the NC2 domain at the BMP1 consensus cleavage site SYAA|DTAG. Mammalian tolloid-like (mTLL)-1 and -2 can substitute for BMP1 (Ratttenholl et al. 2002).
Bruckner-Tuderman, L, Koch, M, Rattenholl, A, Keene, DR, Burgeson, RE, Greenspan, DS, Pappano, WN, Kadler, KE, Timpl, R, Sasaki, T
serine-type endopeptidase activity of Collagen type VII NC2 proteinases [extracellular region]
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