Cleavage of collagen VII NC2 region by BMP1

Stable Identifier
R-HSA-2214330
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Cleavage of collagen VII NC2 region by BMP1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Bone morphogenetic protein-1 (BMP1) cleaves the C-terminal propeptide from human procollagen VII within the NC2 domain at the BMP1 consensus cleavage site SYAA|DTAG. Mammalian tolloid-like (mTLL)-1 and -2 can substitute for BMP1 (Ratttenholl et al. 2002).
Literature References
PubMed ID Title Journal Year
11986329 Proteinases of the bone morphogenetic protein-1 family convert procollagen VII to mature anchoring fibril collagen

Bruckner-Tuderman, L, Koch, M, Rattenholl, A, Keene, DR, Burgeson, RE, Greenspan, DS, Pappano, WN, Kadler, KE, Timpl, R, Sasaki, T

J Biol Chem 2002
Participants
Input
Output
Participates
as an event of
Catalyst Activity

serine-type endopeptidase activity of Collagen type VII NC2 proteinases [extracellular region]

Physical Entity
Collagen type VII NC2 proteinases [extracellular region] (Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
Orthologous Events
Cleavage of collagen VII NC2 region by BMP1 (Caenorhabditis elegans)
Cleavage of collagen VII NC2 region by BMP1 (Mus musculus)
Cleavage of collagen VII NC2 region by BMP1 (Rattus norvegicus)
Cleavage of collagen VII NC2 region by BMP1 (Sus scrofa)
Authored
Jupe, S  (2012-04-30)
Reviewed
Raleigh, S  (2012-10-08)
Ricard-Blum, S  (2012-11-19)
Kalamajski, S  (2012-10-08)
Created
Jupe, S  (2012-04-30)
Cite Us!