Formation of nonameric complex

Stable Identifier
R-HSA-2213241
Type
Reaction [binding]
Species
Homo sapiens
Compartment
lumenal side of endoplasmic reticulum membrane, endoplasmic reticulum lumen
ReviewStatus
5/5
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Formation of nonameric complex
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Progressive addition of two more preformed alpha beta dimers to the invariant chain trimer and alpha beta complex ((alpha beta)1:(Ii)3) forms the complete nonameric structure ((alpha beta:Ii)3). Calnexin then disassociates on egress of the nonameric complex from the ER.
Literature References
PubMed ID Title Journal Year
9312039 Interaction of MHC class II molecules with the invariant chain: role of the invariant chain (81-90) region

Stumptner, P, Benaroch, P

EMBO J 1997
1956401 Formation of a nine-subunit complex by HLA class II glycoproteins and the invariant chain

Marks, MS, Roche, PA, Cresswell, P

Nature 1991
16618111 Invariant chain transmembrane domain trimerization: a step in MHC class II assembly

Dixon, AM, Matthews, EE, Stanley, BJ, Engelman, DM, Dawson, JP

Biochemistry 2006
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Orthologous Events
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Authored
Garapati, P V  (2012-02-21)
Reviewed
Neefjes, J  (2012-05-14)
Created
Garapati, P V  (2012-04-30)
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