Reactome | Formation of MHC II alpha beta heterodimer

Formation of MHC II alpha beta heterodimer

Stable Identifier

R-HSA-2213239

Type

Reaction [binding]

Species

Homo sapiens

Compartment

integral component of lumenal side of endoplasmic reticulum membrane

ReviewStatus

5/5

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Formation of MHC II alpha beta heterodimer

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MHC II alpha and beta chains translocate to the ER and associate noncovalently to form an alpha beta heterodimer (Roche et al. 1991). This heterodimer then associates with a preformed invariant (Ii) chain trimer.

Literature References

PubMed ID	Title	Journal	Year
16242130	Assembly of major histocompatibility complex class II subunits with invariant chain Neumann, J, Koch, N	FEBS Lett	2005
9312039	Interaction of MHC class II molecules with the invariant chain: role of the invariant chain (81-90) region Stumptner, P, Benaroch, P	EMBO J	1997
1956401	Formation of a nine-subunit complex by HLA class II glycoproteins and the invariant chain Marks, MS, Roche, PA, Cresswell, P	Nature	1991
8415765	The segment of invariant chain that is critical for association with major histocompatibility complex class II molecules contains the sequence of a peptide eluted from class II polypeptides Freisewinkel, IM, Schenck, K, Koch, N	Proc Natl Acad Sci U S A	1993