Trafficking of nonameric complex in the endocytic pathway

Stable Identifier
R-HSA-2213235
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
endocytic vesicle membrane, lysosomal membrane
ReviewStatus
5/5
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Trafficking of nonameric complex in the endocytic pathway
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The internalized nonameric complex passes through the endocytic pathway and finally reach the acidic late endosomal/lysosomal compartments, where the Ii component is progressively degraded by proteases. Proteolysis of Ii occurs through sequential cleavages from the lumenal (C-terminal) side, generating cleavage products of approximately 22 kDa (lip22) and 10 kDa (lip10), finally leaving only CLIP bound within the peptide binding groove of MHC II (Landsverk et al. 2009).
Literature References
PubMed ID Title Journal Year
14731593 Targeting of membrane proteins to endosomes and lysosomes

Sandoval, IV, Bakke, O

Trends Cell Biol 1994
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Orthologous Events
Trafficking of nonameric complex in the endocytic pathway (Bos taurus)
Trafficking of nonameric complex in the endocytic pathway (Canis familiaris)
Trafficking of nonameric complex in the endocytic pathway (Danio rerio)
Trafficking of nonameric complex in the endocytic pathway (Mus musculus)
Trafficking of nonameric complex in the endocytic pathway (Rattus norvegicus)
Trafficking of nonameric complex in the endocytic pathway (Sus scrofa)
Authored
Garapati, P V  (2012-02-21)
Reviewed
Neefjes, J  (2012-05-14)
Created
Garapati, P V  (2012-04-30)
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