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Collagen IX is cross-linked to the surface of collagen type II fibrils
Stable Identifier
R-HSA-2213210
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
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Extracellular matrix organization (Homo sapiens)
Collagen formation (Homo sapiens)
Assembly of collagen fibrils and other multimeric structures (Homo sapiens)
Collagen IX is cross-linked to the surface of collagen type II fibrils (Homo sapiens)
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Certain fibril-associated collagens with interrupted triple helices (FACITs) associate with the surface of collagen fibrils, where they may serve to limit fibril fusion and thereby regulate fibril diameter (Gordon & Hahn 2010, Ricard-Blum et al. 2011). Collagen IX cross-linked to the surface of collagen type II fibrils is thought to both regulate fibril diameter and stabilize interfibrillar connections (Eyre et al. 2004). An alternative model suggests that collagen II and XI form a biological alloy (Blaschke et al. 2000).
Literature References
PubMed ID
Title
Journal
Year
14602708
Covalent cross-linking of the NC1 domain of collagen type IX to collagen type II in cartilage
Weis, MA
,
Pietka, T
,
Eyre, DR
,
Wu, JJ
J Biol Chem
2004
Participants
Input
Collagen type II fibril [extracellular region]
(Homo sapiens)
Collagen type IX [extracellular region]
(Homo sapiens)
Output
Collagen type II fibril:Collagen type IX [extracellular region]
(Homo sapiens)
Participates
as an event of
Assembly of collagen fibrils and other multimeric structures (Homo sapiens)
Orthologous Events
Collagen IX is cross-linked to the surface of collagen type II fibrils (Canis familiaris)
Collagen IX is cross-linked to the surface of collagen type II fibrils (Mus musculus)
Collagen IX is cross-linked to the surface of collagen type II fibrils (Sus scrofa)
Collagen IX is cross-linked to the surface of collagen type II fibrils (Xenopus tropicalis)
Authored
Jupe, S (2012-04-30)
Reviewed
Raleigh, S (2012-10-08)
Ricard-Blum, S (2012-11-19)
Kalamajski, S (2012-10-08)
Created
Jupe, S (2012-04-30)
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