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Formation of collagen fibres
Stable Identifier
R-HSA-2213201
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
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Extracellular matrix organization (Homo sapiens)
Collagen formation (Homo sapiens)
Assembly of collagen fibrils and other multimeric structures (Homo sapiens)
Formation of collagen fibres (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Fibrils are components of larger suprafibrillar structures, fibres. The organisation of fibrils varies between tissues; in the cornea fibrils are arranged in parallel within layers but layers have different orientations. In articular cartilage, fibrils are arranged in mostly parallel layers (Wess 2005). Interactions between fibrils are thought to be largely mediated by surface-associated macromolecules, such as anionic glycosaminoglycans (GAGs) and small leucine-rich proteoglycans such as decorin.
Literature References
PubMed ID
Title
Journal
Year
15837520
Collagen fibril form and function
Wess, TJ
Adv Protein Chem
2005
Participants
Input
Collagen fibrils [extracellular region]
(Homo sapiens)
Output
Collagen fibres [extracellular region]
(Homo sapiens)
Participates
as an event of
Assembly of collagen fibrils and other multimeric structures (Homo sapiens)
Orthologous Events
Formation of collagen fibres (Bos taurus)
Formation of collagen fibres (Caenorhabditis elegans)
Formation of collagen fibres (Canis familiaris)
Formation of collagen fibres (Danio rerio)
Formation of collagen fibres (Drosophila melanogaster)
Formation of collagen fibres (Gallus gallus)
Formation of collagen fibres (Mus musculus)
Formation of collagen fibres (Rattus norvegicus)
Formation of collagen fibres (Sus scrofa)
Formation of collagen fibres (Xenopus tropicalis)
Authored
Jupe, S (2012-04-30)
Reviewed
Raleigh, S (2012-10-08)
Ricard-Blum, S (2012-11-19)
Kalamajski, S (2012-10-08)
Created
Jupe, S (2012-04-30)
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