Formation of anchoring fibrils

Stable Identifier
R-HSA-2213195
Type
Reaction [transition]
Species
Homo sapiens
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Collagen VII forms anchoring fibrils, composed of antiparallel dimers that connect the dermis to the epidermis (Bruckner-Tuderman 2009). During fibrillogenesis, the nascent type VII procollagen molecules dimerize in an antiparallel manner. The C-propeptides are then removed by bone morphogenetic protein 1 (Rattenholl et al. 2002) and the processed antiparallel dimers laterally aggregate (Gordon & Hahn 2010).

Literature References
PubMed ID Title Journal Year
11986329 Proteinases of the bone morphogenetic protein-1 family convert procollagen VII to mature anchoring fibril collagen

Rattenholl, A, Pappano, WN, Koch, M, Keene, DR, Kadler, KE, Sasaki, T, Timpl, R, Burgeson, RE, Greenspan, DS, Bruckner-Tuderman, L

J Biol Chem 2002
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