Formation of anchoring fibrils

Stable Identifier
R-HSA-2213195
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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Formation of anchoring fibrils
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Collagen VII forms anchoring fibrils, composed of antiparallel dimers that connect the dermis to the epidermis (Bruckner-Tuderman 2009). During fibrillogenesis, the nascent type VII procollagen molecules dimerize in an antiparallel manner. The C-propeptides are then removed by bone morphogenetic protein 1 (Rattenholl et al. 2002) and the processed antiparallel dimers laterally aggregate (Gordon & Hahn 2010).
Literature References
PubMed ID Title Journal Year
11986329 Proteinases of the bone morphogenetic protein-1 family convert procollagen VII to mature anchoring fibril collagen

Bruckner-Tuderman, L, Koch, M, Rattenholl, A, Keene, DR, Burgeson, RE, Greenspan, DS, Pappano, WN, Kadler, KE, Timpl, R, Sasaki, T

J Biol Chem 2002
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Orthologous Events
Formation of anchoring fibrils (Caenorhabditis elegans)
Formation of anchoring fibrils (Mus musculus)
Formation of anchoring fibrils (Rattus norvegicus)
Formation of anchoring fibrils (Sus scrofa)
Formation of anchoring fibrils (Xenopus tropicalis)
Authored
Jupe, S  (2012-04-30)
Reviewed
Raleigh, S  (2012-10-08)
Ricard-Blum, S  (2012-11-19)
Kalamajski, S  (2012-10-08)
Created
Jupe, S  (2012-04-30)
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