Hemidesmosome formation

Stable Identifier
R-HSA-2213192
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Type XVII collagen is a component of hemidesmosomes (HDs) (Has & Kern 2010). It associates with integrin alpha6beta4 (a6b4) (Hopkinson et al. 1999). The extracellular region of a6b4 extends from the cell membrane into the basement membrane to bind laminins, with a preference for laminin-332 (Hopkinson & Jones 2000, Sugawara et al. 2008), which is a component of anchoring fibrils. Laminins are complex glycoproteins, consisting of alpha, beta and gamma chains bound into a cross-shaped molecule. Laminin-332 is a complex of alpha-3, beta-2 and gamma-2 subunits. The cytoplasmic domain of integrin beta-4 interacts with other hemidesmosomal components, plectrin and BPAG1. The interaction of a6b4 and plectrin is likely to be the initial step in HD formation (de Pereda et al. 2009). The cytoplasmic domain of collagen type XVII (BP180) binds to integrin beta-4, plectin and BPAG1 (Hopkinson & Jones 2000, Koster et al. 2003). The transmembrane protein CD151 (tetraspanin-24) associates with a6b4 (Sterk et al. 2002) and is essential for the correct assembly of basement membranes in human kidney and skin, possibly having a role in integrin alpha-3 maturation and cell surface expression (Karamatic Crew et al. 2003).

Literature References
PubMed ID Title Journal Year
15265795 CD151, the first member of the tetraspanin (TM4) superfamily detected on erythrocytes, is essential for the correct assembly of human basement membranes in kidney and skin

Karamatic Crew, V, Burton, N, Kagan, A, Green, CA, Levene, C, Flinter, F, Brady, RL, Daniels, G, Anstee, DJ

Blood 2004
9856810 Interaction of BP180 (type XVII collagen) and alpha6 integrin is necessary for stabilization of hemidesmosome structure

Hopkinson, SB, Findlay, K, deHart, GW, Jones, JC

J Invest Dermatol 1998
12482924 Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly

Koster, J, Geerts, D, Favre, B, Borradori, L, Sonnenberg, A

J Cell Sci 2003
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