Reactome | DNM3 [cytosol]

DNM3 [cytosol]

Stable Identifier

R-HSA-2213188

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Dynamin-3, DYN3_HUMAN

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Clathrin-mediated endocytosis (Homo sapiens)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        DNM:GDP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        DNM:GDP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
    - BAR domain proteins recruit dynamin (Homo sapiens)
      - DNM:GTP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        DNM:GTP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        DNM:GDP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        DNM:GDP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        DNM:GDP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        DNM:GDP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
    - Dissociation of clathrin-associated proteins (Homo sapiens)
      - DNM:GDP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        DNM:GDP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
      - Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        DNM:GDP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        DNM:GTP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        DNM:GTP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        DNM:GTP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        DNM:GDP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        DNM:GDP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
    - RAB5 and GAPVD1 bind AP-2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        DNM:GDP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        DNM:GTP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        DNM:GTP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UQ16 DNM3

Gene Names

DNM3, KIAA0820

Chain

chain:1-869

Reference Genes

BioGPS Gene:26052 DNM3

COSMIC (genes):DNM3 DNM3

CTD Gene:26052 DNM3

dbSNP Gene:26052 DNM3

ENSEMBL:ENSG00000197959 DNM3

HGNC:29125 DNM3

KEGG:hsa:26052 DNM3

Monarch:26052 DNM3

NCBI Gene:26052 DNM3

OMIM:611445 DNM3

UCSC:Q9UQ16 DNM3

Reference Transcript

Participates

as a candidate of

Dynamin [cytosol] (Homo sapiens)

Other forms of this molecule

DNM3 [plasma membrane]

Inferred To

dyn-1 [cytosol] (Caenorhabditis elegans)

DNM3 [cytosol] (Bos taurus)

DNM3 [cytosol] (Canis familiaris)

DNM3 [cytosol] (Sus scrofa)

Dnm3 [cytosol] (Mus musculus)

Dnm3 [cytosol] (Rattus norvegicus)

shi [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_001337133.1, XP_054191860.1, NP_001129599.1, XP_005245137.1, NP_056384.2, XP_005245136.1, NP_001265181.1

OpenTargets

ENSG00000197959

ENSEMBL

ENST00000367731, ENSP00000347457, ENSG00000197959, ENST00000367733, ENSP00000356707, ENST00000627582, ENSP00000486701, ENSP00000356705, ENST00000355305

IntEnz

3.6.5.5

HPA

ENSG00000197959-DNM3

GeneCards

DNM3

PRO

Q9UQ16

Pharos - Targets

Q9UQ16

PDB

3L43, 5A3F

HMDB Protein

HMDBP08365

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.725	5
UniProt:P50570 DNM2	5	DNM2 [plasma membrane] (R-HSA-2984201) DNM2 [lysosomal membrane] (R-HSA-2980840) DNM2 [cytosol] (R-HSA-2213180) DNM2 [endocytic vesicle membrane] (R-HSA-2029000) DNM2 [Golgi membrane] (R-HSA-2980842)	0.643	5
UniProt:Q05193 DNM1	3	DNM1 [plasma membrane] (R-HSA-177488) DNM1 [lysosomal membrane] (R-HSA-196150) DNM1 [cytosol] (R-HSA-2213182)	0.527	2

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