Reactome | DNM3 [cytosol]

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DNM3

Stable Identifier

R-HSA-2213188

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Dynamin-3, DYN3_HUMAN

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Clathrin-mediated endocytosis (Homo sapiens)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Homo sapiens)
        
        DNM:GDP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated vesicle membrane] (Homo sapiens)
        
        DNM:GDP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
    - BAR domain proteins recruit dynamin (Homo sapiens)
      - DNM:GTP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        DNM:GTP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        DNM:GDP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Homo sapiens)
        
        DNM:GDP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Homo sapiens)
        
        DNM:GDP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Homo sapiens)
        
        DNM:GDP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
    - Dissociation of clathrin-associated proteins (Homo sapiens)
      - DNM:GDP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Homo sapiens)
        
        DNM:GDP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
      - Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        DNM:GDP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        DNM:GTP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        DNM:GTP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        DNM:GTP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Homo sapiens)
        
        DNM:GDP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated vesicle membrane] (Homo sapiens)
        
        DNM:GDP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
    - RAB5 and GAPVD1 bind AP-2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Homo sapiens)
        
        DNM:GDP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        DNM:GTP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        DNM:GTP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UQ16 DNM3

Gene Names

DNM3, KIAA0820

Chain

chain:1-869

Reference Genes

BioGPS Gene:26052 DNM3

COSMIC (genes):DNM3 DNM3

CTD Gene:26052 DNM3

dbSNP Gene:26052 DNM3

ENSEMBL:ENSG00000197959 DNM3

HGNC:29125 DNM3

KEGG Gene (Homo sapiens):hsa:26052 DNM3

Monarch:26052 DNM3

NCBI Gene:26052 DNM3

OMIM:611445 DNM3

UCSC:Q9UQ16 DNM3

Reference Transcript

Other Identifiers

0004210162

11758498_at

1558502_s_at

16673842

209839_at

2367328

2367329

2367348

2367357

2367359

2367364

2367365

2367368

2367370

2367372

2367376

2367378

2367382

2367386

2367400

2367401

2367429

2367439

2367461

2367462

2367463

2367470

2367471

26052

39671_at

3L43

51761_at

5A3F

64121

7907370

A_23_P371266

A_33_P3264364

AAH64546

AB020627

AL031864

AL121984

AL133514

AL136712

AL137157

AL445990

AL512843

BAA74843

BC064546

CAB66647

CAH69969

CAH69970

CAH71040

CAH71041

CAH71951

CAH71952

CAH74079

CAH74080

CAI19054

CAI19055

CAI19211

CAI19212

CAI22007

CAI22008

CCDS44276

CCDS53431

CCDS60356

CH471067

DNM3

DNM3-201

DNM3-202

DNM3-203

DNM3-208

EAW90918

ENSG00000197959

ENSP00000347457

ENSP00000356705

ENSP00000356707

ENSP00000486701

ENST00000355305

ENST00000367731

ENST00000367733

ENST00000627582

EntrezGene:26052

g12052943_3p_at

GE53522

GO:0000166

GO:0000266

GO:0000902

GO:0001917

GO:0003374

GO:0003674

GO:0003924

GO:0005515

GO:0005525

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005737

GO:0005739

GO:0005794

GO:0005856

GO:0005874

GO:0005886

GO:0006461

GO:0006810

GO:0006897

GO:0007005

GO:0007416

GO:0008017

GO:0008092

GO:0008150

GO:0014069

GO:0016185

GO:0016192

GO:0016787

GO:0019899

GO:0022607

GO:0030154

GO:0030424

GO:0031798

GO:0031802

GO:0031966

GO:0043083

GO:0043167

GO:0043197

GO:0043226

GO:0044327

GO:0045202

GO:0046847

GO:0048471

GO:0048856

GO:0050998

GO:0051491

GO:0061001

GO:0061002

GO:0061024

GO:0061025

GO:0065003

GO:0070062

GO:0098844

GO:0098884

HGNC:29125

HPA064121

Hs.654775

Hs2.407324.1.A1_3p_s_at

ILMN_1680928

IPR000375

IPR001401

IPR001849

IPR003130

IPR011993

IPR019762

IPR020850

IPR022812

IPR027417

IPR030381

MIM:611445

NM_001136127

NM_001278252

NM_015569

NP_001129599

NP_001265181

NP_001337133

NP_001337135

NP_056384

PF00169

PF00350

PF01031

PF02212

PH_hs_0023819

PR00195

SM00053

SM00233

SM00302

TC01001498.hg

uc001gid.6

uc001gie.5

uc001gif.5

uc057nia.1

UPI0000129A22

UPI0000231C40

UPI0000251D91

UPI0000458803

XM_005245079

XM_005245080

XM_006711268

XM_017000976

XM_017000977

XM_017000978

XM_017000979

XM_017000980

XM_017000981

XM_017000982

XM_017000983

XM_017000984

XM_017000985

XM_017000986

XM_017000987

XM_017000988

XM_017000989

XM_017000990

XM_017000991

XM_017000992

XP_005245136

XP_005245137

XP_016856465

XP_016856466

XP_016856467

XP_016856468

XP_016856469

XP_016856471

XP_016856472

XP_016856473

XP_016856474

XP_016856475

XP_016856476

XP_016856477

XP_016856478

XP_016856479

XP_016856480

XP_016856481

XR_001737107

XR_001737108

XR_001737109

XR_001737110

XR_001737111

Z97195

Participant Of

hasCandidate

Dynamin [cytosol]

Other forms of this molecule

DNM3 [plasma membrane]

Inferred To

Homologues of DNM3 [cytosol] (Canis familiaris)

Homologues of DNM3 [cytosol] (Danio rerio)

Homologues of DNM3 [cytosol] (Gallus gallus)

Homologues of DNM3 [cytosol] (Sus scrofa)

Homologues of DNM3 [cytosol] (Taeniopygia guttata)

DNM3 [cytosol] (Bos taurus)

DNM3 [cytosol] (Caenorhabditis elegans)

DNM3 [cytosol] (Canis familiaris)

DNM3 [cytosol] (Danio rerio)

DNM3 [cytosol] (Drosophila melanogaster)

DNM3 [cytosol] (Gallus gallus)

DNM3 [cytosol] (Mus musculus)

DNM3 [cytosol] (Rattus norvegicus)

DNM3 [cytosol] (Sus scrofa)

DNM3 [cytosol] (Taeniopygia guttata)

DNM3 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

XP_005245136.1, NP_056384.2, XP_005245137.1, NP_001265181.1, NP_001129599.1

Brenda

3.6.5.5

GeneCards

Q9UQ16

DOCK Blaster

3L43, 5A3F

PRO

Q9UQ16

Orphanet

24489

PDB

3L43, 5A3F

HMDB Protein

HMDBP08365