Reactome | DNM3 [cytosol]

DNM3 [cytosol]

Stable Identifier

R-HSA-2213188

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Dynamin-3, DYN3_HUMAN

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Clathrin-mediated endocytosis (Homo sapiens)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        DNM:GDP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        DNM:GDP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
    - BAR domain proteins recruit dynamin (Homo sapiens)
      - DNM:GTP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        DNM:GTP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        DNM:GDP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        DNM:GDP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        DNM:GDP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        DNM:GDP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
    - Dissociation of clathrin-associated proteins (Homo sapiens)
      - DNM:GDP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        DNM:GDP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
      - Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        DNM:GDP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        DNM:GTP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        DNM:GTP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        DNM:GTP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        DNM:GDP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        DNM:GDP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
    - RAB5 and GAPVD1 bind AP-2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        DNM:GDP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        DNM:GTP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        DNM:GTP [cytosol] (Homo sapiens)
        
        Dynamin [cytosol] (Homo sapiens)
        
        DNM3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UQ16 DNM3

Gene Names

DNM3, KIAA0820

Chain

chain:1-869

Reference Genes

BioGPS Gene:26052 DNM3

COSMIC (genes):DNM3 DNM3

CTD Gene:26052 DNM3

dbSNP Gene:26052 DNM3

ENSEMBL:ENSG00000197959 DNM3

HGNC:29125 DNM3

KEGG Gene (Homo sapiens):26052 DNM3

Monarch:26052 DNM3

NCBI Gene:26052 DNM3

OMIM:611445 DNM3

UCSC:Q9UQ16 DNM3

Reference Transcript

Other Identifiers

0004210162

11758498_at

1558502_PM_s_at

1558502_s_at

16673842

209839_PM_at

209839_at

2367327

2367328

2367329

2367348

2367357

2367359

2367364

2367365

2367368

2367370

2367372

2367376

2367378

2367382

2367386

2367400

2367401

2367429

2367439

2367461

2367462

2367463

2367470

2367471

2367472

2367473

2367488

2367490

2367492

2367494

26052

39671_at

51761_at

7907370

A_23_P371266

A_33_P3264364

GE53522

GO:0000166

GO:0000902

GO:0003674

GO:0003924

GO:0005198

GO:0005515

GO:0005525

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005794

GO:0005856

GO:0005874

GO:0005886

GO:0006810

GO:0006897

GO:0007416

GO:0008017

GO:0008092

GO:0008150

GO:0014069

GO:0016020

GO:0016192

GO:0016787

GO:0019899

GO:0022607

GO:0030154

GO:0030424

GO:0031623

GO:0031798

GO:0031802

GO:0032991

GO:0034330

GO:0042802

GO:0043083

GO:0043167

GO:0043197

GO:0043226

GO:0044327

GO:0045202

GO:0046847

GO:0048471

GO:0048488

GO:0048856

GO:0050998

GO:0051491

GO:0061001

GO:0061002

GO:0061828

GO:0061829

GO:0070062

GO:0098793

GO:0098844

GO:0098884

GO:0098978

GO:0099173

GO:0099186

GO:1903423

HMNXSV003018621

HMNXSV003053984

Hs2.407324.1.A1_3p_s_at

ILMN_1680928

PH_hs_0023819

TC01001498.hg

g12052943_3p_at

Participates

as a candidate of

Dynamin [cytosol] (Homo sapiens)

Other forms of this molecule

DNM3 [plasma membrane]

Inferred To

dyn-1 [cytosol] (Caenorhabditis elegans)

DNM3 [cytosol] (Bos taurus)

DNM3 [cytosol] (Canis familiaris)

DNM3 [cytosol] (Sus scrofa)

dnm3a [cytosol] (Danio rerio)

Dnm3 [cytosol] (Mus musculus)

Dnm3 [cytosol] (Rattus norvegicus)

shi [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_001129599.1, NP_056384.2, XP_005245136.1, NP_001265181.1, XP_005245137.1

OpenTargets

ENSG00000197959

GeneCards

Q9UQ16

HPA

ENSG00000197959-DNM3

Ensembl

ENST00000367733, ENSP00000486701, ENSP00000356707, ENSP00000347457, ENST00000367731, ENSG00000197959, ENST00000355305, ENSP00000356705, ENST00000627582

PRO

Q9UQ16

Pharos - Targets

Q9UQ16

Orphanet

24489

HMDB Protein

HMDBP08365

PDB

3L43, 5A3F

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.527	3

Cite Us!