Reactome | STAB2 (FEEL-2) binds ligands

STAB2 (FEEL-2) binds ligands

Stable Identifier

R-HSA-2203479

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

ReviewStatus

5/5

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STAB2 (FEEL-2) binds acetylated low density lipoprotein (LDL) (Adachi & Tsujimoto 2002, Harris & Weigel 2008), advanced glycation end products (AGE) (Tamura et al. 2003), chondroitin sulfate (Harris & Weigel 2008), hyaluronic acid (Zhou et al. 2003, Harris et al. 2004, Harris et al. 2007, Harris & Weigel 2008), heparin (Harris et al. 2008, Harris & Weigel 2008, Harris et al. 2009), and phosphatidylserne (Park et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18499864	The ligand-binding profile of HARE: hyaluronan and chondroitin sulfates A, C, and D bind to overlapping sites distinct from the sites for heparin, acetylated low-density lipoprotein, dermatan sulfate, and CS-E Weigel, PH, Harris, EN	Glycobiology	2008
18434317	The human hyaluronan receptor for endocytosis (HARE/Stabilin-2) is a systemic clearance receptor for heparin Weigel, PH, Weigel, JA, Harris, EN	J Biol Chem	2008
17962816	Rapid cell corpse clearance by stabilin-2, a membrane phosphatidylserine receptor Park, RW, Kim, IS, Lee, BH, Kim, SY, Kwon, TH, Kim, HJ, Lee, SJ, Jung, MY, Park, SY	Cell Death Differ	2008
12473645	FEEL-1 and FEEL-2 are endocytic receptors for advanced glycation end products Tsujimoto, M, Sekiya, M, Ohashi, K, Nagai, R, Kimura, S, Tamura, Y, Yahagi, N, Tomita, S, Iizuka, Y, Okazaki, H, Shimano, H, Ishibashi, S, Osuga, J, Adachi, H	J Biol Chem	2003
12077138	FEEL-1, a novel scavenger receptor with in vitro bacteria-binding and angiogenesis-modulating activities Tsujimoto, M, Adachi, H	J Biol Chem	2002
12626425	Purification and molecular identification of the human hyaluronan receptor for endocytosis McGary, CT, Weigel, PH, Zhou, B, Saxena, A, Weigel, JA	Glycobiology	2003
15208308	Endocytic function, glycosaminoglycan specificity, and antibody sensitivity of the recombinant human 190-kDa hyaluronan receptor for endocytosis (HARE) Weigel, PH, Weigel, JA, Harris, EN	J Biol Chem	2004
17145755	Expression, processing, and glycosaminoglycan binding activity of the recombinant human 315-kDa hyaluronic acid receptor for endocytosis (HARE) Kyosseva, SV, Weigel, PH, Weigel, JA, Harris, EN	J Biol Chem	2007
19359419	Rat and human HARE/stabilin-2 are clearance receptors for high- and low-molecular-weight heparins Baggenstoss, BA, Weigel, PH, Harris, EN	Am J Physiol Gastrointest Liver Physiol	2009