STAB2 (FEEL-2) binds ligands

Stable Identifier
Reaction [binding]
Homo sapiens
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STAB2 (FEEL-2) binds acetylated low density lipoprotein (LDL) (Adachi & Tsujimoto 2002, Harris & Weigel 2008), advanced glycation end products (AGE) (Tamura et al. 2003), chondroitin sulfate (Harris & Weigel 2008), hyaluronic acid (Zhou et al. 2003, Harris et al. 2004, Harris et al. 2007, Harris & Weigel 2008), heparin (Harris et al. 2008, Harris & Weigel 2008, Harris et al. 2009), and phosphatidylserne (Park et al. 2008).

Literature References
PubMed ID Title Journal Year
18499864 The ligand-binding profile of HARE: hyaluronan and chondroitin sulfates A, C, and D bind to overlapping sites distinct from the sites for heparin, acetylated low-density lipoprotein, dermatan sulfate, and CS-E

Weigel, PH, Harris, EN

Glycobiology 2008
18434317 The human hyaluronan receptor for endocytosis (HARE/Stabilin-2) is a systemic clearance receptor for heparin

Weigel, PH, Weigel, JA, Harris, EN

J Biol Chem 2008
17962816 Rapid cell corpse clearance by stabilin-2, a membrane phosphatidylserine receptor

Park, RW, Kim, IS, Lee, BH, Kim, SY, Kwon, TH, Kim, HJ, Lee, SJ, Jung, MY, Park, SY

Cell Death Differ 2008
12473645 FEEL-1 and FEEL-2 are endocytic receptors for advanced glycation end products

Tsujimoto, M, Sekiya, M, Ohashi, K, Nagai, R, Kimura, S, Tamura, Y, Yahagi, N, Tomita, S, Iizuka, Y, Okazaki, H, Shimano, H, Ishibashi, S, Osuga, J, Adachi, H

J Biol Chem 2003
12077138 FEEL-1, a novel scavenger receptor with in vitro bacteria-binding and angiogenesis-modulating activities

Tsujimoto, M, Adachi, H

J Biol Chem 2002
12626425 Purification and molecular identification of the human hyaluronan receptor for endocytosis

McGary, CT, Weigel, PH, Zhou, B, Saxena, A, Weigel, JA

Glycobiology 2003
15208308 Endocytic function, glycosaminoglycan specificity, and antibody sensitivity of the recombinant human 190-kDa hyaluronan receptor for endocytosis (HARE)

Weigel, PH, Weigel, JA, Harris, EN

J Biol Chem 2004
17145755 Expression, processing, and glycosaminoglycan binding activity of the recombinant human 315-kDa hyaluronic acid receptor for endocytosis (HARE)

Kyosseva, SV, Weigel, PH, Weigel, JA, Harris, EN

J Biol Chem 2007
19359419 Rat and human HARE/stabilin-2 are clearance receptors for high- and low-molecular-weight heparins

Baggenstoss, BA, Weigel, PH, Harris, EN

Am J Physiol Gastrointest Liver Physiol 2009
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