Reactome | SCARB1 (SR-BI, CLA-1) binds ligands

SCARB1 (SR-BI, CLA-1) binds ligands

Stable Identifier

R-HSA-2197646

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

ReviewStatus

5/5

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SCARB1 (SR-BI) binds low density lipoprotein (LDL), acetylated LDL, oxidized LDL, high density lipoprotein (HDL) (Calvo et al. 1997, Murao et al. 1997, Rhainds et al. 1999, inferred from hamster in Acton et al. 1994). SCARB1 binds HDL via its protein moiety, including apolipoproteins A-I, A-II, CII, CIII and E (Bultel-Brienne et al. 2002, inferred from mouse in Xu, Laccotripe et al. 1997, Li et al. 2002). SCARB1 also binds serum amyloid A protein (Baranova et al. 2005), and lipopolysaccharide (LPS) (Vishnyakova et al. 2003). SCARB1 is expressed on the extracellular face of the plasma membrane of several types of polarized epithelial cells.

Literature References

PubMed ID	Title	Journal	Year
15576377	Serum amyloid A binding to CLA-1 (CD36 and LIMPII analogous-1) mediates serum amyloid A protein-induced activation of ERK1/2 and p38 mitogen-activated protein kinases Baranova, IN, Thomas, F, Remaley, AT, Kimelman, ML, Kurlander, R, Patterson, AP, Csako, G, Eggerman, TL, Bocharov, AV, Chen, Z, Vishnyakova, TG	J Biol Chem	2005
12651854	Binding and internalization of lipopolysaccharide by Cla-1, a human orthologue of rodent scavenger receptor B1 Baranova, IN, Remaley, AT, Patterson, AP, Csako, G, Eggerman, TL, Bocharov, AV, Chen, Z, Vishnyakova, TG	J Biol Chem	2003
9254056	Apolipoproteins of HDL can directly mediate binding to the scavenger receptor SR-BI, an HDL receptor that mediates selective lipid uptake Laccotripe, M, Huang, X, Zannis, VI, Krieger, M, Xu, S, Rigotti, A	J. Lipid Res.	1997
12138091	Lipid free apolipoprotein E binds to the class B Type I scavenger receptor I (SR-BI) and enhances cholesteryl ester uptake from lipoproteins Clavey, V, Laffont, I, Tailleux, A, Siest, G, Fruchart, JC, Pilon, A, Lestavel, S, Bultel-Brienne, S	J. Biol. Chem.	2002
10103054	Uptake and fate of class B scavenger receptor ligands in HepG2 cells Tremblay, C, Rhainds, D, Falstrault, L, Brissette, L	Eur J Biochem	1999
9211901	Characterization of CLA-1, a human homologue of rodent scavenger receptor BI, as a receptor for high density lipoprotein and apoptotic thymocytes Terpstra, V, Green, SR, Murao, K, Kondratenko, N, Steinberg, D, Quehenberger, O	J Biol Chem	1997
11861652	Reconstituted discoidal ApoE-phospholipid particles are ligands for the scavenger receptor BI. The amino-terminal 1-165 domain of ApoE suffices for receptor binding Krieger, M, Lavrentiadou, S, Li, X, Zannis, V, Kan, HY	J. Biol. Chem.	2002
9409200	CLA-1 is an 85-kD plasma membrane glycoprotein that acts as a high-affinity receptor for both native (HDL, LDL, and VLDL) and modified (OxLDL and AcLDL) lipoproteins Vega, MA, Lasunción, MA, Gómez-Coronado, D, Calvo, D	Arterioscler Thromb Vasc Biol	1997