SCARB1 (SR-BI, CLA-1) binds ligands

Stable Identifier
R-HSA-2197646
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Reaction
Species
Homo sapiens
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SCARB1 (SR-BI) binds low density lipoprotein (LDL), acetylated LDL, oxidized LDL, high density lipoprotein (HDL) (Calvo et al. 1997, Murao et al. 1997, Rhainds et al. 1999, inferred from hamster in Acton et al. 1994). SCARB1 binds HDL via its protein moiety, including apolipoproteins A-I, A-II, CII, CIII and E (Bultel-Brienne et al. 2002, inferred from mouse in Xu, Laccotripe et al. 1997, Li et al. 2002). SCARB1 also binds serum amyloid A protein (Baranova et al. 2005), and lipopolysaccharide (LPS) (Vishnyakova et al. 2003). SCARB1 is expressed on the extracellular face of the plasma membrane of several types of polarized epithelial cells.

Literature References
PubMed ID Title Journal Year
12651854 Binding and internalization of lipopolysaccharide by Cla-1, a human orthologue of rodent scavenger receptor B1

Vishnyakova, TG, Bocharov, AV, Baranova, IN, Chen, Z, Remaley, AT, Csako, G, Eggerman, TL, Patterson, AP

J Biol Chem 2003
15576377 Serum amyloid A binding to CLA-1 (CD36 and LIMPII analogous-1) mediates serum amyloid A protein-induced activation of ERK1/2 and p38 mitogen-activated protein kinases

Baranova, IN, Vishnyakova, TG, Bocharov, AV, Kurlander, R, Chen, Z, Kimelman, ML, Remaley, AT, Csako, G, Thomas, F, Eggerman, TL, Patterson, AP

J Biol Chem 2005
9254056 Apolipoproteins of HDL can directly mediate binding to the scavenger receptor SR-BI, an HDL receptor that mediates selective lipid uptake

Xu, S, Laccotripe, M, Huang, X, Rigotti, A, Zannis, VI, Krieger, M

J. Lipid Res. 1997
12138091 Lipid free apolipoprotein E binds to the class B Type I scavenger receptor I (SR-BI) and enhances cholesteryl ester uptake from lipoproteins

Bultel-Brienne, S, Lestavel, S, Pilon, A, Laffont, I, Tailleux, A, Fruchart, JC, Siest, G, Clavey, V

J. Biol. Chem. 2002
10103054 Uptake and fate of class B scavenger receptor ligands in HepG2 cells

Rhainds, D, Falstrault, L, Tremblay, C, Brissette, L

Eur J Biochem 1999
9211901 Characterization of CLA-1, a human homologue of rodent scavenger receptor BI, as a receptor for high density lipoprotein and apoptotic thymocytes

Murao, K, Terpstra, V, Green, SR, Kondratenko, N, Steinberg, D, Quehenberger, O

J Biol Chem 1997
11861652 Reconstituted discoidal ApoE-phospholipid particles are ligands for the scavenger receptor BI. The amino-terminal 1-165 domain of ApoE suffices for receptor binding

Li, X, Kan, HY, Lavrentiadou, S, Krieger, M, Zannis, V

J. Biol. Chem. 2002
9409200 CLA-1 is an 85-kD plasma membrane glycoprotein that acts as a high-affinity receptor for both native (HDL, LDL, and VLDL) and modified (OxLDL and AcLDL) lipoproteins

Calvo, D, Gómez-Coronado, D, Lasunción, MA, Vega, MA

Arterioscler Thromb Vasc Biol 1997
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