SCARF1 (SREC-I) binds ligands

Stable Identifier
Reaction [binding]
Homo sapiens
Related Species
Neisseria gonorrhoeae
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SCARF1 (SREC-I) binds low density lipoprotein (LDL), oxidized LDL, acetylated LDL (Adachi et al. 1997), carbamylated LDL (Apostolov et al. 2009), beta glucan (Means et al. 2009), and calreticulin (Berwin et al. 2004). SREC-I binds Hsp90 and Hsp90-chaperoned peptides (Murshid et al. 2010) as well as Heat shock protein 110 (hsp110) and glucose-regulated protein (grp170) (inferred from mouse, Facciponte, Wang et al. 2007). SREC-I interacts with PorB of Neisseria gonorrhoeae and mediates host cell entry (Rechner et al. 2007).
Literature References
PubMed ID Title Journal Year
17615582 Hsp110 and Grp170, members of the Hsp70 superfamily, bind to scavenger receptor-A and scavenger receptor expressed by endothelial cells-I

Subjeck, JR, Facciponte, JG, Wang, XY

Eur. J. Immunol. 2007
18078691 Host glycoprotein Gp96 and scavenger receptor SREC interact with PorB of disseminating Neisseria gonorrhoeae in an epithelial invasion pathway

Rechner, C, Rudel, T, Kühlewein, C, Schild, H, Müller, A

Cell Host Microbe 2007
20686127 Heat shock protein 90 mediates efficient antigen cross presentation through the scavenger receptor expressed by endothelial cells-I

Murshid, A, Gong, J, Calderwood, SK

J. Immunol. 2010
19696406 Scavenger receptors of endothelial cells mediate the uptake and cellular proatherogenic effects of carbamylated LDL

Apostolov, EO, Basnakian, AG, Ray, D, Shah, SV

Arterioscler. Thromb. Vasc. Biol. 2009
15371419 SREC-I, a type F scavenger receptor, is an endocytic receptor for calreticulin

Lovingood, RV, Post, SR, Berwin, B, Pizzo, SV, Delneste, Y

J Biol Chem 2004
19237602 Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36

Hickman, SE, Means, TK, Stewart, CR, Tampakakis, E, Moore, KJ, Hacohen, N, Luster, AD, Puckett, L, Colvin, RA, Calderwood, SB, Pukkila-Worley, R, Seung, E, El Khoury, J, Tai, MF, Mylonakis, E

J Exp Med 2009
9395444 Expression cloning of a novel scavenger receptor from human endothelial cells

Tsujimoto, M, Arai, H, Inoue, K, Adachi, H

J Biol Chem 1997
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