Reactome | Collagen type XXV [endoplasmic reticulum lumen]

Collagen type XXV [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-2192641

Type

Complex

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

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General

COL25A1 is a brain-specific membrane-bound collagen. Proteolytic processing releases CLAC (collagenous Alzheimer amyloid plaque component), a soluble form of COL25A1 containing the extracellular collagen domains. CLAC associates with amyloid beta peptides (Abeta) in the brains of patients with Alzheimer's disease, inhibiting amyloid fibril formation (Osada et al. 2005).

Participants

components

x 3 Alpha-1(XXV) chains [endoplasmic reticulum lumen] (Homo sapiens)

Participates

as a member of

Transmembrane collagens [endoplasmic reticulum lumen] (Homo sapiens)

Inferred To

C-linked procollagen type XXV trimer [endoplasmic reticulum lumen] (Bos taurus)

C-linked procollagen type XXV trimer [endoplasmic reticulum lumen] (Canis familiaris)

C-linked procollagen type XXV trimer [endoplasmic reticulum lumen] (Gallus gallus)

C-linked procollagen type XXV trimer [endoplasmic reticulum lumen] (Mus musculus)

C-linked procollagen type XXV trimer [endoplasmic reticulum lumen] (Rattus norvegicus)

C-linked procollagen type XXV trimer [endoplasmic reticulum lumen] (Sus scrofa)

C-linked procollagen type XXV trimer [endoplasmic reticulum lumen] (Xenopus tropicalis)

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