Collagen type XXV [endoplasmic reticulum lumen]

Stable Identifier
R-HSA-2192641
Type
Complex
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General

COL25A1 is a brain-specific membrane-bound collagen. Proteolytic processing releases CLAC (collagenous Alzheimer amyloid plaque component), a soluble form of COL25A1 containing the extracellular collagen domains. CLAC associates with amyloid beta peptides (Abeta) in the brains of patients with Alzheimer's disease, inhibiting amyloid fibril formation (Osada et al. 2005).

Participants
Participant Of
Inferred To