Dephosphorylated SMAD2/3 translocates to the cytosol

Stable Identifier
R-HSA-2187395
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Dephosphorylated SMAD2/3 translocates to the cytosol
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
After dephosphorylation by PPM1A, SMAD2 and SMAD3 translocate to the cytosol.
Literature References
PubMed ID Title Journal Year
16751101 PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling

Wrighton, KH, Shi, Y, Liang, YY, Brunicardi, FC, Duan, X, Feng, XH, Chen, YG, Su, Y, Lin, X, Hu, M, Meng, A, Wang, J, Davis, CM, Long, J

Cell 2006
Participants
Input
Output
Participates
as an event of
Orthologous Events
Dephosphorylated SMAD2/3 translocates to the cytosol (Bos taurus)
Dephosphorylated SMAD2/3 translocates to the cytosol (Caenorhabditis elegans)
Dephosphorylated SMAD2/3 translocates to the cytosol (Canis familiaris)
Dephosphorylated SMAD2/3 translocates to the cytosol (Danio rerio)
Dephosphorylated SMAD2/3 translocates to the cytosol (Drosophila melanogaster)
Dephosphorylated SMAD2/3 translocates to the cytosol (Gallus gallus)
Dephosphorylated SMAD2/3 translocates to the cytosol (Mus musculus)
Dephosphorylated SMAD2/3 translocates to the cytosol (Rattus norvegicus)
Dephosphorylated SMAD2/3 translocates to the cytosol (Sus scrofa)
Dephosphorylated SMAD2/3 translocates to the cytosol (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2012-04-05)
Reviewed
Huang, T  (2012-05-14)
Contreras, O  (2022-05-02)
Created
Orlic-Milacic, M  (2012-04-10)
Cite Us!