SMAD3, ubiquitinated by STUB1 (CHIP), is degraded in a proteasome-dependent manner. STUB1-mediated downregulation of SMAD3 level happens in the absence of TGF-beta stimulation. STUB1 may therefore keep the basal level of SMAD3 low in the absence of TGF-beta signaling (Li et al. 2004, Xin et al. 2005).
Zhang, S, Fu, XY, Xin, H, Li, L, Zhang, X, Chang, Z, Chen, Y, Xu, X, Huang, M
Fu, XY, Xin, H, Li, L, Chang, Z, Rong, Y, Xu, X, Ning, H, Shang, Y, Wang, Y
© 2022 Reactome
