SMAD3, ubiquitinated by STUB1 (CHIP), is degraded in a proteasome-dependent manner. STUB1-mediated downregulation of SMAD3 level happens in the absence of TGF-beta stimulation. STUB1 may therefore keep the basal level of SMAD3 low in the absence of TGF-beta signaling (Li et al. 2004, Xin et al. 2005).
Xin, H, Xu, X, Li, L, Ning, H, Rong, Y, Shang, Y, Wang, Y, Fu, XY, Chang, Z
Li, L, Xin, H, Xu, X, Huang, M, Zhang, X, Chen, Y, Zhang, S, Fu, XY, Chang, Z
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