Degradation of ubiquitinated SMAD3

Stable Identifier
Reaction [omitted]
Homo sapiens
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SMAD3, ubiquitinated by STUB1 (CHIP), is degraded in a proteasome-dependent manner. STUB1-mediated downregulation of SMAD3 level happens in the absence of TGF-beta stimulation. STUB1 may therefore keep the basal level of SMAD3 low in the absence of TGF-beta signaling (Li et al. 2004, Xin et al. 2005).

Literature References
PubMed ID Title Journal Year
15781469 CHIP controls the sensitivity of transforming growth factor-beta signaling by modulating the basal level of Smad3 through ubiquitin-mediated degradation

Xin, H, Xu, X, Li, L, Ning, H, Rong, Y, Shang, Y, Wang, Y, Fu, XY, Chang, Z

J Biol Chem 2005
14701756 CHIP mediates degradation of Smad proteins and potentially regulates Smad-induced transcription

Li, L, Xin, H, Xu, X, Huang, M, Zhang, X, Chen, Y, Zhang, S, Fu, XY, Chang, Z

Mol Cell Biol 2004
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