Reactome | Degradation of ubiquitinated SMAD3

Degradation of ubiquitinated SMAD3

Stable Identifier

R-HSA-2187382

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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SMAD3, ubiquitinated by STUB1 (CHIP), is degraded in a proteasome-dependent manner. STUB1-mediated downregulation of SMAD3 level happens in the absence of TGF-beta stimulation. STUB1 may therefore keep the basal level of SMAD3 low in the absence of TGF-beta signaling (Li et al. 2004, Xin et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
14701756	CHIP mediates degradation of Smad proteins and potentially regulates Smad-induced transcription Zhang, S, Fu, XY, Xin, H, Li, L, Zhang, X, Chang, Z, Chen, Y, Xu, X, Huang, M	Mol Cell Biol	2004
15781469	CHIP controls the sensitivity of transforming growth factor-beta signaling by modulating the basal level of Smad3 through ubiquitin-mediated degradation Fu, XY, Xin, H, Li, L, Chang, Z, Rong, Y, Xu, X, Ning, H, Shang, Y, Wang, Y	J Biol Chem	2005