PARP1 binds SMAD2/3:SMAD4 heterotrimer

Stable Identifier
R-HSA-2187330
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PARP1 binds SMAD2/3:SMAD4 heterotrimer
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PARP1 (poly [ADP-ribose] polymerase 1) binds SMAD2/3:SMAD4 heterotrimers associated with DNA SMAD-binding elements (SBEs).

Literature References
PubMed ID Title Journal Year
21095583 PARP-1 attenuates Smad-mediated transcription

Dahl, M, Lönn, P, Moustakas, A, Hellman, U, van der Heide, LP, Heldin, CH

Mol Cell 2010
Participants
Input
Output
Participates
as an event of
Orthologous Events
PARP1 binds SMAD2/3:SMAD4 heterotrimer (Bos taurus)
PARP1 binds SMAD2/3:SMAD4 heterotrimer (Canis familiaris)
PARP1 binds SMAD2/3:SMAD4 heterotrimer (Danio rerio)
PARP1 binds SMAD2/3:SMAD4 heterotrimer (Drosophila melanogaster)
PARP1 binds SMAD2/3:SMAD4 heterotrimer (Mus musculus)
PARP1 binds SMAD2/3:SMAD4 heterotrimer (Rattus norvegicus)
PARP1 binds SMAD2/3:SMAD4 heterotrimer (Sus scrofa)
PARP1 binds SMAD2/3:SMAD4 heterotrimer (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2012-04-05)
Reviewed
Huang, T  (2012-05-14)
Contreras, O  (2022-05-02)
Created
Orlic-Milacic, M  (2012-04-09)
Cite Us!