COLEC12 (SCARA4) binds ligands

Stable Identifier
R-HSA-2187261
Type
Reaction
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
COLEC12 (SCARA4) binds ligands
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

COLEC12 (SCARA4) binds beta-glucan (Jang et al. 2009), N-acetylgalactosamine (Yoshida et al. 2003), oxidized LDL (Ohtani et al. 2001), and double-stranded RNA (DeWitte-Orr et al. 2010). COLEC12 is expressed on endothelial cells

Literature References
PubMed ID Title Journal Year
12761161 SRCL/CL-P1 recognizes GalNAc and a carcinoma-associated antigen, Tn antigen

Yoshida, T, Tsuruta, Y, Iwasaki, M, Yamane, S, Ochi, T, Suzuki, R

J Biochem 2003
19073604 Scavenger receptor collectin placenta 1 (CL-P1) predominantly mediates zymosan phagocytosis by human vascular endothelial cells

Jang, S, Ohtani, K, Fukuoh, A, Yoshizaki, T, Fukuda, M, Motomura, W, Mori, K, Fukuzawa, J, Kitamoto, N, Yoshida, I, Suzuki, Y, Wakamiya, N

J Biol Chem 2009
20360967 An accessory to the 'Trinity': SR-As are essential pathogen sensors of extracellular dsRNA, mediating entry and leading to subsequent type I IFN responses

DeWitte-Orr, SJ, Collins, SE, Bauer, CM, Bowdish, DM, Mossman, KL

PLoS Pathog 2010
11564734 The membrane-type collectin CL-P1 is a scavenger receptor on vascular endothelial cells

Ohtani, K, Suzuki, Y, Eda, S, Kawai, T, Kase, T, Keshi, H, Sakai, Y, Fukuoh, A, Sakamoto, T, Itabe, H, Suzutani, T, Ogasawara, M, Yoshida, I, Wakamiya, N

J Biol Chem 2001
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
COLEC12 (SCARA4) binds ligands (Danio rerio)
COLEC12 (SCARA4) binds ligands (Xenopus tropicalis)
Authored
Neyen, C  (2013-03-22)
May, B  (2013-01-27)
Reviewed
Neyen, C  (2013-03-22)
Created
May, B  (2012-04-07)