COLEC12 (SCARA4) binds ligands

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
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COLEC12 (SCARA4) binds beta-glucan (Jang et al. 2009), N-acetylgalactosamine (Yoshida et al. 2003), oxidized LDL (Ohtani et al. 2001), and double-stranded RNA (DeWitte-Orr et al. 2010). COLEC12 is expressed on endothelial cells
Literature References
PubMed ID Title Journal Year
19073604 Scavenger receptor collectin placenta 1 (CL-P1) predominantly mediates zymosan phagocytosis by human vascular endothelial cells

Motomura, W, Fukuda, M, Jang, S, Kitamoto, N, Fukuzawa, J, Yoshida, I, Fukuoh, A, Ohtani, K, Wakamiya, N, Suzuki, Y, Yoshizaki, T, Mori, K

J Biol Chem 2009
12761161 SRCL/CL-P1 recognizes GalNAc and a carcinoma-associated antigen, Tn antigen

Tsuruta, Y, Ochi, T, Suzuki, R, Yamane, S, Iwasaki, M, Yoshida, T

J Biochem 2003
20360967 An accessory to the 'Trinity': SR-As are essential pathogen sensors of extracellular dsRNA, mediating entry and leading to subsequent type I IFN responses

DeWitte-Orr, SJ, Mossman, KL, Bowdish, DM, Bauer, CM, Collins, SE

PLoS Pathog 2010
11564734 The membrane-type collectin CL-P1 is a scavenger receptor on vascular endothelial cells

Sakamoto, T, Keshi, H, Kase, T, Sakai, Y, Kawai, T, Yoshida, I, Fukuoh, A, Ohtani, K, Wakamiya, N, Suzuki, Y, Suzutani, T, Ogasawara, M, Itabe, H, Eda, S

J Biol Chem 2001
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