SKI/SKIL ubiquitinated by RNF111 (Levy et al. 2007, Nagano et al. 2007) or SMURF2 (Bonni et al. 2001) are degraded in a proteasome dependent way, enabling transcription of SMAD2/3:SMAD4 target genes.
Nagano, Y, Mavrakis, KJ, Lee, KL, Fujii, T, Koinuma, D, Sase, H, Yuki, K, Isogaya, K, Saitoh, M, Imamura, T, Episkopou, V, Miyazono, K, Miyazawa, K
Levy, L, Howell, M, Das, D, Harkin, S, Episkopou, V, Hill, CS
Bonni, S, Wang, HR, Causing, CG, Kavsak, P, Stroschein, SL, Luo, K, Wrana, JL
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