Degradation of ubiquitinated SKI/SKIL

Stable Identifier
R-HSA-2186767
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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SKI/SKIL ubiquitinated by RNF111 (Levy et al. 2007, Nagano et al. 2007) or SMURF2 (Bonni et al. 2001) are degraded in a proteasome dependent way, enabling transcription of SMAD2/3:SMAD4 target genes.
Literature References
PubMed ID Title Journal Year
17591695 Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation

Episkopou, V, Levy, L, Harkin, S, Hill, CS, Das, D, Howell, M

Mol Cell Biol 2007
17510063 Arkadia induces degradation of SnoN and c-Ski to enhance transforming growth factor-beta signaling

Episkopou, V, Miyazono, K, Yuki, K, Nagano, Y, Lee, KL, Imamura, T, Isogaya, K, Saitoh, M, Koinuma, D, Mavrakis, KJ, Fujii, T, Sase, H, Miyazawa, K

J Biol Chem 2007
11389444 TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation

Wrana, JL, Luo, K, Bonni, S, Wang, HR, Stroschein, SL, Causing, CG, Kavsak, P

Nat Cell Biol 2001
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