Reactome | Degradation of ubiquitinated SKI/SKIL

Degradation of ubiquitinated SKI/SKIL

Stable Identifier

R-HSA-2186767

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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SKI/SKIL ubiquitinated by RNF111 (Levy et al. 2007, Nagano et al. 2007) or SMURF2 (Bonni et al. 2001) are degraded in a proteasome dependent way, enabling transcription of SMAD2/3:SMAD4 target genes.

Literature References

PubMed ID	Title	Journal	Year
17591695	Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation Levy, L, Howell, M, Das, D, Harkin, S, Episkopou, V, Hill, CS	Mol Cell Biol	2007
17510063	Arkadia induces degradation of SnoN and c-Ski to enhance transforming growth factor-beta signaling Nagano, Y, Mavrakis, KJ, Lee, KL, Fujii, T, Koinuma, D, Sase, H, Yuki, K, Isogaya, K, Saitoh, M, Imamura, T, Episkopou, V, Miyazono, K, Miyazawa, K	J Biol Chem	2007
11389444	TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation Bonni, S, Wang, HR, Causing, CG, Kavsak, P, Stroschein, SL, Luo, K, Wrana, JL	Nat Cell Biol	2001