TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer

Stable Identifier
R-HSA-2186607
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Transcriptional repressors TGIF1 and TGIF2 bind SMAD2/3:SMAD4 heterotrimer through interaction with SMAD2 and/or SMAD3. TGIF1 and TGIF2 recruit hystone deacetylase HDAC1 to SMAD2/3:SMAD4 heterotrimer.

Literature References
PubMed ID Title Journal Year
11427533 TGIF2 interacts with histone deacetylase 1 and represses transcription

Melhuish, TA, Gallo, CM, Wotton, D

J Biol Chem 2001
10199400 A Smad transcriptional corepressor

Wotton, D, Lo, RS, Lee, S, Massague, J

Cell 1999
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created