TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer

Stable Identifier
R-HSA-2186607
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer
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Transcriptional repressors TGIF1 and TGIF2 bind SMAD2/3:SMAD4 heterotrimer through interaction with SMAD2 and/or SMAD3. TGIF1 and TGIF2 recruit hystone deacetylase HDAC1 to SMAD2/3:SMAD4 heterotrimer.
Literature References
PubMed ID Title Journal Year
10199400 A Smad transcriptional corepressor

Massague, J, Lee, S, Lo, RS, Wotton, D

Cell 1999
11427533 TGIF2 interacts with histone deacetylase 1 and represses transcription

Melhuish, TA, Gallo, CM, Wotton, D

J Biol Chem 2001
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Orthologous Events
TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Bos taurus)
TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Caenorhabditis elegans)
TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Canis familiaris)
TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Drosophila melanogaster)
TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Mus musculus)
TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Rattus norvegicus)
TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Sus scrofa)
Authored
Orlic-Milacic, M  (2012-04-05)
Reviewed
Huang, T  (2012-05-14)
Contreras, O  (2022-05-02)
Created
Orlic-Milacic, M  (2012-04-04)
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