Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor

Stable Identifier
Reaction [BlackBoxEvent]
Homo sapiens
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The heparin-binding EGF growth factor (HBEGF) is a member of the EGF family of growth factors that binds to and activates the EGF receptor EGFR/ErbB1 and ErbB4 (not shown here) (Higashiyama et al. 1991, Elenius et al. 1997). The details which describe receptor dimerisation on ligand binding and autophosphorylation from experiments in mice have been omitted here.

Literature References
PubMed ID Title Journal Year
1840698 A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF

Higashiyama, S, Abraham, JA, Miller, J, Fiddes, JC, Klagsbrun, M

Science 1991
9135143 Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation

Elenius, K, Paul, S, Allison, G, Sun, J, Klagsbrun, M

EMBO J 1997
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Orthologous Events
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