Reactome | Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor

Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor

Stable Identifier

R-HSA-2179387

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor

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The heparin-binding EGF growth factor (HBEGF) is a member of the EGF family of growth factors that binds to and activates the EGF receptor EGFR/ErbB1 and ErbB4 (not shown here) (Higashiyama et al. 1991, Elenius et al. 1997). The details which describe receptor dimerisation on ligand binding and autophosphorylation from experiments in mice have been omitted here.

Literature References

PubMed ID	Title	Journal	Year
9135143	Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation Sun, J, Paul, S, Allison, G, Klagsbrun, M, Elenius, K	EMBO J	1997
1840698	A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF Miller, J, Abraham, JA, Fiddes, JC, Higashiyama, S, Klagsbrun, M	Science	1991