SMURF2 binds SMAD3 phosphorylated in the linker region

Stable Identifier
R-HSA-2179274
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
SMURF2 binds SMAD3 phosphorylated in the linker region
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
SMURF2 binds SMAD2/3:SMAD4 heterotrimer through ineraction with SMAD3. Phosphorylation of threonine T179 in the linker region of SMAD3 is critical for SMURF2 binding. SMURF2 also interacts with SMAD2 phosphorylated in the linker region.
Literature References
PubMed ID Title Journal Year
22045334 Ablation of Smurf2 reveals an inhibition in TGF-? signalling through multiple mono-ubiquitination of Smad3

Tang, LY, Yamashita, M, Coussens, NP, Tang, Y, Wang, X, Li, C, Deng, CX, Cheng, SY, Zhang, YE

EMBO J 2011
Participants
Input
Output
Participates
as an event of
Orthologous Events
SMURF2 binds SMAD3 phosphorylated in the linker region (Bos taurus)
SMURF2 binds SMAD3 phosphorylated in the linker region (Canis familiaris)
SMURF2 binds SMAD3 phosphorylated in the linker region (Drosophila melanogaster)
SMURF2 binds SMAD3 phosphorylated in the linker region (Gallus gallus)
SMURF2 binds SMAD3 phosphorylated in the linker region (Mus musculus)
SMURF2 binds SMAD3 phosphorylated in the linker region (Rattus norvegicus)
SMURF2 binds SMAD3 phosphorylated in the linker region (Sus scrofa)
SMURF2 binds SMAD3 phosphorylated in the linker region (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2012-04-05)
Reviewed
Huang, T  (2012-05-14)
Contreras, O  (2022-05-02)
Created
Orlic-Milacic, M  (2012-04-03)
Cite Us!