SMURF2 binds SMAD3 phosphorylated in the linker region

Stable Identifier
R-HSA-2179274
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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SMURF2 binds SMAD3 phosphorylated in the linker region
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SMURF2 binds SMAD2/3:SMAD4 heterotrimer through ineraction with SMAD3. Phosphorylation of threonine T179 in the linker region of SMAD3 is critical for SMURF2 binding. SMURF2 also interacts with SMAD2 phosphorylated in the linker region.

Literature References
PubMed ID Title Journal Year
22045334 Ablation of Smurf2 reveals an inhibition in TGF-? signalling through multiple mono-ubiquitination of Smad3

Zhang, YE, Coussens, NP, Tang, LY, Li, C, Tang, Y, Deng, CX, Yamashita, M, Cheng, SY, Wang, X

EMBO J 2011
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Orthologous Events
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SMURF2 binds SMAD3 phosphorylated in the linker region (Canis familiaris)
SMURF2 binds SMAD3 phosphorylated in the linker region (Danio rerio)
SMURF2 binds SMAD3 phosphorylated in the linker region (Drosophila melanogaster)
SMURF2 binds SMAD3 phosphorylated in the linker region (Mus musculus)
SMURF2 binds SMAD3 phosphorylated in the linker region (Rattus norvegicus)
SMURF2 binds SMAD3 phosphorylated in the linker region (Sus scrofa)
SMURF2 binds SMAD3 phosphorylated in the linker region (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2012-04-05)
Reviewed
Huang, T  (2012-05-14)
Contreras, O  (2022-05-02)
Created
Orlic-Milacic, M  (2012-04-03)
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