Degradation of SMAD2/3:SMAD4 complex

Stable Identifier
R-HSA-2176503
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
nucleoplasm
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Degradation of SMAD2/3:SMAD4 complex
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NEDD4L-mediated ubiquitination of SMAD2/3 triggers degradation and ends transcriptional activity of SMAD2/3:SMAD4 complex.

Literature References
PubMed ID Title Journal Year
19917253 Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling

Massague, J, Chen, PY, Macias, MJ, Tempst, P, Goerner, N, Gao, S, Sapkota, G, Alarcon, C, Erdjument-Bromage, H, Rahman, S

Mol Cell 2009
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Orthologous Events
Degradation of SMAD2/3:SMAD4 complex (Caenorhabditis elegans)
Degradation of SMAD2/3:SMAD4 complex (Canis familiaris)
Degradation of SMAD2/3:SMAD4 complex (Danio rerio)
Degradation of SMAD2/3:SMAD4 complex (Drosophila melanogaster)
Degradation of SMAD2/3:SMAD4 complex (Gallus gallus)
Degradation of SMAD2/3:SMAD4 complex (Mus musculus)
Degradation of SMAD2/3:SMAD4 complex (Rattus norvegicus)
Degradation of SMAD2/3:SMAD4 complex (Sus scrofa)
Degradation of SMAD2/3:SMAD4 complex (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2012-04-04)
Reviewed
Huang, T  (2012-05-14)
Created
Orlic-Milacic, M  (2012-04-02)
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