Degradation of SMAD2/3:SMAD4 complex

Stable Identifier
R-HSA-2176503
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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NEDD4L-mediated ubiquitination of SMAD2/3 triggers degradation and ends transcriptional activity of SMAD2/3:SMAD4 complex.

Literature References
PubMed ID Title Journal Year
19917253 Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling

Gao, S, Alarcon, C, Sapkota, G, Rahman, S, Chen, PY, Goerner, N, Macias, MJ, Erdjument-Bromage, H, Tempst, P, Massague, J

Mol Cell 2009
Participants
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Orthologous Events
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Created