Reactome | Degradation of ubiquitinated SMAD2

Degradation of ubiquitinated SMAD2

Stable Identifier

R-HSA-2176452

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol

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Ubiquitinated SMAD2 undergoes proteasome-dependent degradation. Therefore, SMURF2 decreases the level of SMAD2 in the cell, irrespective of TGF-beta signaling, and may regulate the competence of a cell to respond to TGF-beta signaling (Zhang et al. 2001). These findings are contradicted by a recent study of Smurf2 knockout mice, where Smad2 protein levels were found to be unaltered in the absence of Smurf2 (Tang et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
11158580	Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase Zhang, Y, Chang, C, Gehling, DJ, Hemmati-Brivanlou, A, Derynck, R	Proc Natl Acad Sci U S A	2001
22045334	Ablation of Smurf2 reveals an inhibition in TGF-? signalling through multiple mono-ubiquitination of Smad3 Tang, LY, Yamashita, M, Coussens, NP, Tang, Y, Wang, X, Li, C, Deng, CX, Cheng, SY, Zhang, YE	EMBO J	2011