Degradation of ubiquitinated SMAD2

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Reaction [BlackBoxEvent]
Homo sapiens
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Ubiquitinated SMAD2 undergoes proteasome-dependent degradation. Therefore, SMURF2 decreases the level of SMAD2 in the cell, irrespective of TGF-beta signaling, and may regulate the competence of a cell to respond to TGF-beta signaling (Zhang et al. 2001). These findings are contradicted by a recent study of Smurf2 knockout mice, where Smad2 protein levels were found to be unaltered in the absence of Smurf2 (Tang et al. 2011).

Literature References
PubMed ID Title Journal Year
22045334 Ablation of Smurf2 reveals an inhibition in TGF-? signalling through multiple mono-ubiquitination of Smad3

Zhang, YE, Coussens, NP, Tang, LY, Li, C, Tang, Y, Deng, CX, Yamashita, M, Cheng, SY, Wang, X

EMBO J 2011
11158580 Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

Zhang, Y, Gehling, DJ, Chang, C, Hemmati-Brivanlou, A, Derynck, R

Proc Natl Acad Sci U S A 2001
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