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SMURF2 binds SMAD2
Stable Identifier
R-HSA-2176445
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
TGF-beta receptor signaling activates SMADs (Homo sapiens)
Downregulation of TGF-beta receptor signaling (Homo sapiens)
SMURF2 binds SMAD2 (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
SMURF2 binds SMAD2 irrespective of TGF-beta signaling (Zhang et al. 2001).
Literature References
PubMed ID
Title
Journal
Year
11158580
Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase
Zhang, Y
,
Gehling, DJ
,
Chang, C
,
Hemmati-Brivanlou, A
,
Derynck, R
Proc Natl Acad Sci U S A
2001
Participants
Input
SMAD2 [cytosol]
(Homo sapiens)
SMURF2 [cytosol]
(Homo sapiens)
Output
SMAD2:SMURF2 [cytosol]
(Homo sapiens)
Participates
as an event of
Downregulation of TGF-beta receptor signaling (Homo sapiens)
Orthologous Events
SMURF2 binds SMAD2 (Bos taurus)
SMURF2 binds SMAD2 (Canis familiaris)
SMURF2 binds SMAD2 (Danio rerio)
SMURF2 binds SMAD2 (Drosophila melanogaster)
SMURF2 binds SMAD2 (Gallus gallus)
SMURF2 binds SMAD2 (Mus musculus)
SMURF2 binds SMAD2 (Rattus norvegicus)
SMURF2 binds SMAD2 (Sus scrofa)
SMURF2 binds SMAD2 (Xenopus tropicalis)
Authored
Orlic-Milacic, M (2012-04-05)
Reviewed
Huang, T (2012-05-14)
Created
Orlic-Milacic, M (2012-04-02)
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