Reactome | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer

Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer

Stable Identifier

R-HSA-2173793

DOI

10.3180/R-HSA-2173793.3

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer

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In the nucleus, SMAD2/3:SMAD4 heterotrimer complex acts as a transcriptional regulator. The activity of SMAD2/3 complex is regulated both positively and negatively by association with other transcription factors (Chen et al. 2002, Varelas et al. 2008, Stroschein et al. 1999, Wotton et al. 1999). In addition, the activity of SMAD2/3:SMAD4 complex can be inhibited by nuclear protein phosphatases and ubiquitin ligases (Lin et al. 2006, Dupont et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
12150994	E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression Massague, J, Siegel, PM, Chen, CR, Kang, Y	Cell	2002
10531062	Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein Zhou, Q, Luo, K, Zhou, S, Stroschein, SL, Wang, W	Science	1999
19135894	FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination Stinchfield, MJ, Montagner, M, Morsut, L, Piccolo, S, Inui, M, Moro, S, Mamidi, A, Newfeld, SJ, Soligo, S, Dupont, S, Argenton, F, Martello, G, Modena, N, Adorno, M, Zacchigna, L, Cordenonsi, M	Cell	2009
10199400	A Smad transcriptional corepressor Massague, J, Lee, S, Lo, RS, Wotton, D	Cell	1999
18568018	TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal Wrana, JL, Peerani, R, Rao, BM, Samavarchi-Tehrani, P, Sakuma, R, Zandstra, PW, Varelas, X, Yaffe, MB, Dembowy, J	Nat Cell Biol	2008
16751101	PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling Wrighton, KH, Shi, Y, Liang, YY, Brunicardi, FC, Duan, X, Feng, XH, Chen, YG, Su, Y, Lin, X, Hu, M, Meng, A, Wang, J, Davis, CM, Long, J	Cell	2006