MARCO (SCARA2) binds ligands

Stable Identifier
Reaction [binding]
Homo sapiens
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Unlike MSR1, MARCO uses the SRCR domain and more particularly the arginine-rich region within this domain for binding. (Brannstrom et al. 2002). MARCO binds lipopolysaccharide and lipoteichoic acid, both found on the surfaces of bacteria (Elomaa et al. 1998, Elshourbagy et al. 2000). MARCO binds and phagocytoses Streptococcus pneumoniae (mouse, Dorrington et al. 2013), Escherichia coli and Staphylococcus aureus (Elshourbagy, Li et al. 2000), Neisseria meningitidis (Mukhopadhyay et al. 2006), Clostridium sordellii (Thelen et al. 2010). MARCO binds proinflammatory oxidized lipids (mouse, Dahl et al. 2007). MARCO binds CpG oligonucleotide sequences (CpG-ODN) in microbial DNA (mouse, Jozefowski et al. 2006), uteroglobin-related protein 1 (Bin et al. 2003), unopsonized particles (TiO2, Fe2O3, and latex beads) (Palecanda et al. 1999) and silica particles (Hamilton et al. 2006). MARCO is most strongly expressed on subgroups of macrophages and can also be detected on splenic dendritic cells.

Literature References
PubMed ID Title Journal Year
10224290 Role of the scavenger receptor MARCO in alveolar macrophage binding of unopsonized environmental particles

Kobzik, L, Kodama, T, Palecanda, A, Tryggvason, K, Imrich, A, Al-Mutairi, E, Koziel, H, Suzuki, H, Qin, G, Paulauskis, J

J. Exp. Med. 1999
17332894 Protection against inhaled oxidants through scavenging of oxidized lipids by macrophage receptors MARCO and SR-AI/II

Kobzik, L, Kleeberger, SR, Soininen, R, Arredouani, M, Dahl, M, Bauer, AK, Tryggvason, K

J. Clin. Invest. 2007
9468508 Structure of the human macrophage MARCO receptor and characterization of its bacteria-binding region

Pikkarainen, T, Tuuttila, A, Bergmann, U, Tryggvason, K, Elomaa, O, Sankala, M, Sariola, H, Raatikainen-Ahokas, A

J Biol Chem 1998
16525990 MARCO, an innate activation marker of macrophages, is a class A scavenger receptor for Neisseria meningitidis

Gordon, S, Kraal, G, Chen, Y, Pikkarainen, T, Peiser, L, Sankala, M, Tryggvason, K, Mukhopadhyay, S

Eur. J. Immunol. 2006
16882874 Role of scavenger receptor MARCO in macrophage responses to CpG oligodeoxynucleotides

Kobzik, L, Sulahian, TH, Arredouani, M, Józefowski, S

J. Leukoc. Biol. 2006
10651831 Molecular characterization of a human scavenger receptor, human MARCO

Elshourbagy, NA, Webb, CL, Li, X, Lysko, PG, Adamou, JE, Gross, MS, Anderson, KM, Vanhorn, S, Terrett, J

Eur J Biochem 2000
20810988 The class A scavenger receptor, macrophage receptor with collagenous structure, is the major phagocytic receptor for Clostridium sordellii expressed by human decidual macrophages

Medeiros, AI, Aronoff, DM, Kobzik, L, Serezani, CH, Harris, LH, Curtis, JL, Hao, Y, Thelen, T

J Immunol 2010
23197261 MARCO is required for TLR2- and Nod2-mediated responses to Streptococcus pneumoniae and clearance of pneumococcal colonization in the murine nasopharynx

Weiser, JN, Roche, AM, Mossman, KL, Chauvin, SE, Dorrington, MG, Bowdish, DM, Tu, Z

J. Immunol. 2013
16984918 MARCO mediates silica uptake and toxicity in alveolar macrophages from C57BL/6 mice

Holian, A, Mayfair, JK, Thakur, SA, Hamilton, RF

J. Biol. Chem. 2006
12847263 Identification of uteroglobin-related protein 1 and macrophage scavenger receptor with collagenous structure as a lung-specific ligand-receptor pair

Nielson, LD, Shu, HB, Bin, LH, Mason, RJ, Liu, X

J. Immunol. 2003
11820786 Arginine residues in domain V have a central role for bacteria-binding activity of macrophage scavenger receptor MARCO

Pikkarainen, T, Brännström, A, Sankala, M, Tryggvason, K

Biochem. Biophys. Res. Commun. 2002
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