MSR1 (SCARA1, SR-A) binds ligands

Stable Identifier
R-HSA-2173778
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
MSR1 (SCARA1, SR-A) binds ligands
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
MSR1 (SCARA1, SR-A) binds oxidized and acetylated low density lipid (LDL) particles ((Brown et al. 1980), Haberland et al 1984, Gough et al. 1998, Yang et al. 2011), apolipoproteins A-I and E (human and mouse, Neyen et al. 2009), lysophosphatidylcholine from apoptotic cells (mouse, Sakai et al. 1996), phosphatidylinositol and phosphatidylserine (mouse, Nishikawa et al. 1990). MSR1 binds activated B-lymphocytes (human, Yokota et al. 1998), calreticulin and gp96 (mouse, Berwin et al. 2003). MSR1 binds bacterial products (E.coli, Neisseria meningitides, Staphylococcus aureus) (mouse, Peiser et al. 2006), Lipopolysaccharide (LPS) (mouse and bovine, Hampton et al. 1991), Lipoteichoic acid (LTA) and Gram-positive bacteria (bovine, Dunne et al. 1994), Adenovirus 5 (Haisma et al. 2009). MSR1 binds polysaccharides (carrageenan, dextran sulphate, fucoidan) (Brown et al. 1980, Krieger et al. 1992), extracellular matrix proteoglycans, biglycan and decorin (mouse, Santiago-Garcia et al. 2003). MSR1 binds extracellular matrix molecules, including denatured type I and III collagen, as well as glycated collagen IV (human and mouse and bovine, el Khoury et al. 1994, Gowen et al. 2000, Gowen et al. 2001), beta-amyloid fibrils (human and mouse, El Khoury et al. 1996), maleyl-BSA and advanced glycation end-product modified (AGE)-BSA (bovine, Brown et al. 1980, Araki et al. 1995). MSR1 binds polynucleotides (polyI, polyG) (bovine, Brown et al. 1980, Pearson et al. 1993, Mielewczyk et al. 1996), double-stranded RNA (Limmon et al. 2008, DeWitte-Orr et al. 2010). MSR1 interacts with the modified apoB-100 component of LDL (Parthasarathy et al. 1987) and with the lipid part of LDL (Terpstra et al. 1998). MSR1 is expressed most strongly on macrophages and can also be detected on endothelial cells and smooth muscle cells.
Literature References
PubMed ID Title Journal Year
9465098 Evidence that the lipid moiety of oxidized low density lipoprotein plays a role in its interaction with macrophage receptors

Terpstra, V, Bird, DA, Steinberg, D

Proc. Natl. Acad. Sci. U.S.A. 1998
8784195 Binding studies of a triple-helical peptide model of macrophage scavenger receptor to tetraplex nucleic acids

Mielewczyk, SS, Breslauer, KJ, Anachi, RB, Brodsky, B

Biochemistry 1996
16926412 Identification of Neisseria meningitidis nonlipopolysaccharide ligands for class A macrophage scavenger receptor by using a novel assay

Peiser, L, Makepeace, K, Plüddemann, A, Savino, S, Wright, JC, Pizza, M, Rappuoli, R, Moxon, ER, Gordon, S

Infect. Immun. 2006
6255257 The scavenger cell pathway for lipoprotein degradation: specificity of the binding site that mediates the uptake of negatively-charged LDL by macrophages

Brown, MS, Basu, SK, Falck, JR, Ho, YK, Goldstein, JL

J. Supramol. Struct. 1980
6088540 Role of lysines in mediating interaction of modified low density lipoproteins with the scavenger receptor of human monocyte macrophages

Haberland, ME, Olch, CL, Folgelman, AM

J Biol Chem 1984
9511720 Scavenger receptors mediate adhesion of activated B lymphocytes

Yokota, T, Ehlin-Henriksson, B, Hansson, GK

Exp. Cell Res. 1998
9548586 A naturally occurring isoform of the human macrophage scavenger receptor (SR-A) gene generated by alternative splicing blocks modified LDL uptake

Gough, PJ, Greaves, DR, Gordon, S

J Lipid Res 1998
20360967 An accessory to the 'Trinity': SR-As are essential pathogen sensors of extracellular dsRNA, mediating entry and leading to subsequent type I IFN responses

DeWitte-Orr, SJ, Collins, SE, Bauer, CM, Bowdish, DM, Mossman, KL

PLoS Pathog 2010
2318890 Scavenger receptor-mediated uptake and metabolism of lipid vesicles containing acidic phospholipids by mouse peritoneal macrophages

Nishikawa, K, Arai, H, Inoue, K

J. Biol. Chem. 1990
12488451 The class A scavenger receptor binds to proteoglycans and mediates adhesion of macrophages to the extracellular matrix

Santiago-García, J, Kodama, T, Pitas, RE

J. Biol. Chem. 2003
10686426 Selective adhesion of macrophages to denatured forms of type I collagen is mediated by scavenger receptors

Gowen, BB, Borg, TK, Ghaffar, A, Mayer, EP

Matrix Biol. 2000
1852209 Recognition and plasma clearance of endotoxin by scavenger receptors

Hampton, RY, Golenbock, DT, Penman, M, Krieger, M, Raetz, CR

Nature 1991
14609958 Scavenger receptor-A mediates gp96/GRP94 and calreticulin internalization by antigen-presenting cells

Berwin, B, Hart, JP, Rice, S, Gass, C, Pizzo, SV, Post, SR, Nicchitta, CV

EMBO J. 2003
17709607 Scavenger receptor class-A is a novel cell surface receptor for double-stranded RNA

Limmon, GV, Arredouani, M, McCann, KL, Corn Minor, RA, Kobzik, L, Imani, F

FASEB J. 2008
19227971 Scavenger receptor A: a new route for adenovirus 5

Haisma, HJ, Boesjes, M, Beerens, AM, van der Strate, BW, Curiel, DT, Plüddemann, A, Gordon, S, Bellu, AR

Mol. Pharm. 2009
1339697 Molecular flypaper, atherosclerosis, and host defense: structure and function of the macrophage scavenger receptor

Krieger, M, Abrams, JM, Lux, A, Steller, H

Cold Spring Harb. Symp. Quant. Biol. 1992
8127896 The type I macrophage scavenger receptor binds to gram-positive bacteria and recognizes lipoteichoic acid

Dunne, DW, Resnick, D, Greenberg, J, Krieger, M, Joiner, KA

Proc. Natl. Acad. Sci. U.S.A. 1994
8429030 Polynucleotide binding to macrophage scavenger receptors depends on the formation of base-quartet-stabilized four-stranded helices

Pearson, AM, Rich, A, Krieger, M

J. Biol. Chem. 1993
9225214 Endocytic uptake of lysophosphatidylcholine mediated by macrophage scavenger receptor plays a major role in oxidized low density lipoprotein-induced macrophage growth

Sakai, M, Miyazaki, A, Hakamata, H, Kobori, S, Shichiri, M, Horiuchi, S

J. Atheroscler. Thromb. 1996
3467373 Recognition of solubilized apoproteins from delipidated, oxidized low density lipoprotein (LDL) by the acetyl-LDL receptor

Parthasarathy, S, Fong, LG, Otero, D, Steinberg, D

Proc. Natl. Acad. Sci. U.S.A. 1987
19911804 Macrophage scavenger receptor A mediates adhesion to apolipoproteins A-I and E

Neyen, C, Plüddemann, A, Roversi, P, Thomas, B, Cai, L, van der Westhuyzen, DR, Sim, RB, Gordon, S

Biochemistry 2009
8751442 Scavenger receptor-mediated adhesion of microglia to beta-amyloid fibrils

El Khoury, J, Hickman, SE, Thomas, CA, Cao, L, Silverstein, SC, Loike, JD

Nature 1996
21782039 Effect of overexpression of human SR-AI on oxLDL uptake and apoptosis in 293T cells

Yang, H, Chen, SC, Tang, YQ, Dai, YL

Int Immunopharmacol 2011
7607209 Macrophage scavenger receptor mediates the endocytic uptake and degradation of advanced glycation end products of the Maillard reaction

Araki, N, Higashi, T, Mori, T, Shibayama, R, Kawabe, Y, Kodama, T, Takahashi, K, Shichiri, M, Horiuchi, S

Eur. J. Biochem. 1995
Participants
Input
Output
Participates
as an event of
Inferred From
Msr1 (Scara1) Binds Ligands (Mus musculus)
Authored
Neyen, C  (2013-03-22)
May, B  (2013-01-27)
Reviewed
Neyen, C  (2013-03-22)
Created
May, B  (2012-04-02)
Cite Us!