PHF8 demethylates histone H4K20me1

Stable Identifier
R-HSA-2172678
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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PHF8 demethylates histone H4K20me1
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PHF8, a PHD and Jumonji C domain-containing protein, is recruited to chromatin by binding to dimethylated or trimethylated histone H3 - H3K4me2 and/or H3K4me3. PHF8 demethylates monomethylated histone H4, H4K20me1, a docking site for the condesin II complex (Liu et al. 2010).
Literature References
PubMed ID Title Journal Year
20622854 PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression

Liu, W, Tanasa, B, Tyurina, OV, Zhou, TY, Gassmann, R, Liu, WT, Ohgi, KA, Benner, C, Garcia-Bassets, I, Aggarwal, AK, Desai, A, Dorrestein, PC, Glass, CK, Rosenfeld, MG

Nature 2010
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Catalyst Activity

histone H4K20 demethylase activity of PHF8:Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm]

Physical Entity
PHF8:Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Homo sapiens)
Activity
histone H4K20 demethylase activity (GO:0035575)
Orthologous Events
PHF8 demethylates histone H4K20me1 (Bos taurus)
PHF8 demethylates histone H4K20me1 (Canis familiaris)
PHF8 demethylates histone H4K20me1 (Danio rerio)
PHF8 demethylates histone H4K20me1 (Dictyostelium discoideum)
PHF8 demethylates histone H4K20me1 (Rattus norvegicus)
PHF8 demethylates histone H4K20me1 (Saccharomyces cerevisiae)
PHF8 demethylates histone H4K20me1 (Schizosaccharomyces pombe)
PHF8 demethylates histone H4K20me1 (Sus scrofa)
PHF8 demethylates histone H4K20me1 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2013-04-23)
Reviewed
Longworth, MS  (2013-10-14)
Created
Orlic-Milacic, M  (2012-03-30)
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