Reactome | FMO2:FAD:Mg2+ S-oxidises MTZ

FMO2:FAD:Mg2+ S-oxidises MTZ

Stable Identifier

R-HSA-217258

Type

Reaction [transition]

Species

Homo sapiens

Compartment

smooth endoplasmic reticulum

Synonyms

FMO2 S-oxidizes the antithyroid drug methimazole

ReviewStatus

5/5

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Methimazole is a drug used to treat hyperthyroidism, a condition arising when the thyroid gland is producing too much thyroid hormone. FMO2 is able to the S-oxidized form of methimazole.

Literature References

PubMed ID	Title	Journal	Year
11744609	Identification of active flavin-containing monooxygenase isoform 2 in human lung and characterization of expressed protein Krueger, SK, Martin, SR, Yueh, MF, Pereira, CB, Williams, DE	Drug Metab Dispos	2002