FMO2:FAD:Mg2+ S-oxidises MTZ

Stable Identifier
R-HSA-217258
Type
Reaction [transition]
Species
Homo sapiens
Compartment
smooth endoplasmic reticulum
Synonyms
FMO2 S-oxidizes the antithyroid drug methimazole
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FMO2:FAD:Mg2+ S-oxidises MTZ
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Methimazole is a drug used to treat hyperthyroidism, a condition arising when the thyroid gland is producing too much thyroid hormone. FMO2 is able to the S-oxidized form of methimazole.

Literature References
PubMed ID Title Journal Year
11744609 Identification of active flavin-containing monooxygenase isoform 2 in human lung and characterization of expressed protein

Krueger, SK, Martin, SR, Yueh, MF, Pereira, CB, Williams, DE

Drug Metab Dispos 2002
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
monooxygenase activity of FMO2:FAD:Mg2+ [endoplasmic reticulum membrane]
Physical Entity
FMO2:FAD:Mg2+ [endoplasmic reticulum membrane]
Activity
monooxygenase activity (0004497)
Orthologous Events
FMO2:FAD:Mg2+ S-oxidises MTZ (Bos taurus)
FMO2:FAD:Mg2+ S-oxidises MTZ (Canis familiaris)
FMO2:FAD:Mg2+ S-oxidises MTZ (Dictyostelium discoideum)
FMO2:FAD:Mg2+ S-oxidises MTZ (Mus musculus)
FMO2:FAD:Mg2+ S-oxidises MTZ (Rattus norvegicus)
FMO2:FAD:Mg2+ S-oxidises MTZ (Sus scrofa)
FMO2:FAD:Mg2+ S-oxidises MTZ (Xenopus tropicalis)
Authored
Jassal, B  (2008-05-19)
Reviewed
D'Eustachio, P  (2008-05-28)
Created
Jassal, B  (2008-03-26)