Collagen type XXIII ectodomain shedding

Stable Identifier
R-HSA-2172405
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Collagen type XXIII is a type II transmembrane collagen with a relatively small ectodomain. It exists in a membrane-bound form and a shed form, cleaved by furin (Veit et al. 2007). Both forms can bind alpha2beta1 integrin via the ectodomain, stimulating the formation of focal adhesion plaques (Veit et al. 2011).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of FURIN [plasma membrane]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created