Reactome | Degradation of TGF-beta receptor complex

Degradation of TGF-beta receptor complex

Stable Identifier

R-HSA-2169046

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Degradation of TGF-beta receptor complex

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Recruitment of SMURF1 (Ebisawa et al. 2001), SMURF2 (Kavsak et al. 2000) or NEDD4L (Kuratomi et al. 2005) to the activated TGF-beta receptor complex by SMAD7 and subsequent ubiquitination of SMAD7 and/or TGFBR1 triggers degradation of SMAD7 and TGFBR1 through proteasome and lysosome-dependent routes, resulting in downregulation of signaling by TGF-beta receptors.

Literature References

PubMed ID	Title	Journal	Year
11278251	Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation Ebisawa, T, Fukuchi, M, Murakami, G, Chiba, T, Tanaka, K, Imamura, T, Miyazono, K	J Biol Chem	2001
15496141	NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor Kuratomi, G, Komuro, A, Goto, K, Shinozaki, M, Miyazawa, K, Miyazono, K, Imamura, T	Biochem J	2005
11163210	Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation Kavsak, P, Rasmussen, RK, Causing, CG, Bonni, S, Zhu, H, Thomsen, GH, Wrana, JL	Mol Cell	2000