Recruitment of SMURF1 (Ebisawa et al. 2001), SMURF2 (Kavsak et al. 2000) or NEDD4L (Kuratomi et al. 2005) to the activated TGF-beta receptor complex by SMAD7 and subsequent ubiquitination of SMAD7 and/or TGFBR1 triggers degradation of SMAD7 and TGFBR1 through proteasome and lysosome-dependent routes, resulting in downregulation of signaling by TGF-beta receptors.
Kuratomi, G, Komuro, A, Goto, K, Shinozaki, M, Miyazawa, K, Miyazono, K, Imamura, T
Ebisawa, T, Fukuchi, M, Murakami, G, Chiba, T, Tanaka, K, Imamura, T, Miyazono, K
Kavsak, P, Rasmussen, RK, Causing, CG, Bonni, S, Zhu, H, Thomsen, GH, Wrana, JL
© 2021 Reactome
