Reactome | Haptoglobin-related Protein binds Hemoglobin

Haptoglobin-related Protein binds Hemoglobin

Stable Identifier

R-HSA-2168889

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Formation of Trypanosome Lytic Factor1

ReviewStatus

5/5

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Haptoglobin-related Protein binds Hemoglobin

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Haptoglobin-related protein (HRP) is present in human serum in a complex known as trypanosome lytic factor-1 (TLF-1) that contains APOL1, APOA1, and HDL3. The HPR subunit of the complex binds hemoglobin with an unknown stoichiometry (Shiflett et al. 2005, Nielsen et al. 2006, Widener et al. 2007, Harrington et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19324878	Membrane permeabilization by trypanosome lytic factor, a cytolytic human high density lipoprotein Hajduk, SL, Harrington, JM, Howell, S	J Biol Chem	2009
16046400	Human high density lipoproteins are platforms for the assembly of multi-component innate immune complexes Shiflett, AM, Hajduk, SL, Bishop, JR, Pahwa, A	J Biol Chem	2005
16778136	Haptoglobin-related protein is a high-affinity hemoglobin-binding plasma protein Møller, HJ, Petersen, SV, Moestrup, SK, Jacobsen, C, Rees, D, Nielsen, MJ, Oxvig, C	Blood	2006
17845074	Hemoglobin is a co-factor of human trypanosome lytic factor Hajduk, S, Shiflett, A, Moestrup, SK, Nielsen, MJ, Widener, J	PLoS Pathog	2007