Haptoglobin-related Protein binds Hemoglobin

Stable Identifier
Reaction [binding]
Homo sapiens
Formation of Trypanosome Lytic Factor1
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Haptoglobin-related protein (HRP) is present in human serum in a complex known as trypanosome lytic factor-1 (TLF-1) that contains APOL1, APOA1, and HDL3. The HPR subunit of the complex binds hemoglobin with an unknown stoichiometry (Shiflett et al. 2005, Nielsen et al. 2006, Widener et al. 2007, Harrington et al. 2009).

Literature References
PubMed ID Title Journal Year
16046400 Human high density lipoproteins are platforms for the assembly of multi-component innate immune complexes

Shiflett, AM, Bishop, JR, Pahwa, A, Hajduk, SL

J Biol Chem 2005
19324878 Membrane permeabilization by trypanosome lytic factor, a cytolytic human high density lipoprotein

Harrington, JM, Howell, S, Hajduk, SL

J Biol Chem 2009
16778136 Haptoglobin-related protein is a high-affinity hemoglobin-binding plasma protein

Nielsen, MJ, Petersen, SV, Jacobsen, C, Oxvig, C, Rees, D, Møller, HJ, Moestrup, SK

Blood 2006
17845074 Hemoglobin is a co-factor of human trypanosome lytic factor

Widener, J, Nielsen, MJ, Shiflett, A, Moestrup, SK, Hajduk, S

PLoS Pathog 2007
Orthologous Events
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