Haptoglobin-related Protein binds Hemoglobin

Stable Identifier
R-HSA-2168889
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Formation of Trypanosome Lytic Factor1
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Haptoglobin-related protein (HRP) is present in human serum in a complex known as trypanosome lytic factor-1 (TLF-1) that contains APOL1, APOA1, and HDL3. The HPR subunit of the complex binds hemoglobin with an unknown stoichiometry (Shiflett et al. 2005, Nielsen et al. 2006, Widener et al. 2007, Harrington et al. 2009).

Literature References
PubMed ID Title Journal Year
19324878 Membrane permeabilization by trypanosome lytic factor, a cytolytic human high density lipoprotein

Hajduk, SL, Harrington, JM, Howell, S

J Biol Chem 2009
16046400 Human high density lipoproteins are platforms for the assembly of multi-component innate immune complexes

Shiflett, AM, Hajduk, SL, Bishop, JR, Pahwa, A

J Biol Chem 2005
16778136 Haptoglobin-related protein is a high-affinity hemoglobin-binding plasma protein

Møller, HJ, Petersen, SV, Moestrup, SK, Jacobsen, C, Rees, D, Nielsen, MJ, Oxvig, C

Blood 2006
17845074 Hemoglobin is a co-factor of human trypanosome lytic factor

Hajduk, S, Shiflett, A, Moestrup, SK, Nielsen, MJ, Widener, J

PLoS Pathog 2007
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