Haptoglobin binds Hemoglobin

Stable Identifier
Reaction [binding]
Homo sapiens
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Haptoglobin is an acute phase protein. It is produced by the liver and secreted into the plasma where it binds alpha-beta dimers of hemoglobin (Hamaguchi et al. 1971, Nagel and Gibson 1971, Tsapis et al. 1978, reviewed in Chiabrando et al. 2011). Haptoglobin monomers contain alpha and beta chains cleaved from a single proprotein and bonded by cystine disulfide bonds. The monomers further associate into dimers by disulfide-bonding and beta strand swapping (Andersen et al. 2012). Each haptoglobin dimer can bind two hemoglobin dimers, each containing hemoglobin alpha and hemoglobin beta.

Literature References
PubMed ID Title Journal Year
  Acute Phase Proteins

Veas, F

1252417 Kinetics of deoxyhemoglobin subunit dissociation determined by haptoglobin binding: estimation of the equilibrium constant from forward and reverse rates

Ip, SH, Johnson, ML, Ackers, GK

Biochemistry 1976
7378053 Haemoglobin binding with haptoglobin. Unequivocal demonstration that the beta-chains of human haemoglobin bind to haptoglobin

Kazim, AL, Atassi, MZ

Biochem J 1980
5135507 Studies on the structures of haptoglobin 1-1 and hemoglobin in the haptoglobin-hemoglobin complex

Waks, M, Kahn, PC, Beychok, S

Biochem Biophys Res Commun 1971
7263686 Haptoglobin-hemoglobin complex. Subunit interaction probed by cross-linking

Greer, J, Liao, WD, Brown, WE

J Biol Chem 1981
22922649 Structure of the haptoglobin-haemoglobin complex

Andersen, CB, Torvund-Jensen, M, Nielsen, MJ, de Oliveira, CL, Hersleth, HP, Andersen, NH, Pedersen, JS, Andersen, GR, Moestrup, SK

Nature 2012
13472068 The binding of haemoglobin by plasma proteins (haptoglobins); its bearing on the renal threshold for haemoglobin and the aetiology of haemoglobinuria

Allison, AC, REES, WA

Br Med J 1957
13342742 [Isolation of the haptoglobin-hemoglobin complex in human blood in homogenous state. II]


Bull Soc Chim Biol (Paris) 1956
4327491 Some spectral properties of the human hemoglobin-haptoglobin complex

Hamaguchi, H, Isomoto, A, Miyake, Y, Nakajima, H

Biochemistry 1971
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