Reactome | Haptoglobin binds Hemoglobin

Haptoglobin binds Hemoglobin

Stable Identifier

R-HSA-2168885

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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Haptoglobin is an acute phase protein. It is produced by the liver and secreted into the plasma where it binds alpha-beta dimers of hemoglobin (Hamaguchi et al. 1971, Nagel and Gibson 1971, Tsapis et al. 1978, reviewed in Chiabrando et al. 2011). Haptoglobin monomers contain alpha and beta chains cleaved from a single proprotein and bonded by cystine disulfide bonds. The monomers further associate into dimers by disulfide-bonding and beta strand swapping (Andersen et al. 2012). Each haptoglobin dimer can bind two hemoglobin dimers, each containing hemoglobin alpha and hemoglobin beta.

Literature References

PubMed ID	Title	Journal	Year
1252417	Kinetics of deoxyhemoglobin subunit dissociation determined by haptoglobin binding: estimation of the equilibrium constant from forward and reverse rates Ackers, GK, Ip, SH, Johnson, ML	Biochemistry	1976
	Acute Phase Proteins Veas, F		2011
7378053	Haemoglobin binding with haptoglobin. Unequivocal demonstration that the beta-chains of human haemoglobin bind to haptoglobin Kazim, AL, Atassi, MZ	Biochem J	1980
5135507	Studies on the structures of haptoglobin 1-1 and hemoglobin in the haptoglobin-hemoglobin complex Waks, M, Beychok, S, Kahn, PC	Biochem Biophys Res Commun	1971
7263686	Haptoglobin-hemoglobin complex. Subunit interaction probed by cross-linking Brown, WE, Liao, WD, Greer, J	J Biol Chem	1981
22922649	Structure of the haptoglobin-haemoglobin complex Moestrup, SK, Nielsen, MJ, Pedersen, JS, Andersen, NH, Hersleth, HP, Torvund-Jensen, M, Andersen, GR, Andersen, CB, de Oliveira, CL	Nature	2012
13472068	The binding of haemoglobin by plasma proteins (haptoglobins); its bearing on the renal threshold for haemoglobin and the aetiology of haemoglobinuria Allison, AC, REES, WA	Br Med J	1957
13342742	[Isolation of the haptoglobin-hemoglobin complex in human blood in homogenous state. II] JAYLE, MF, TONNELAT, J, Boussier, G	Bull Soc Chim Biol (Paris)	1956
4327491	Some spectral properties of the human hemoglobin-haptoglobin complex Hamaguchi, H, Miyake, Y, Isomoto, A, Nakajima, H	Biochemistry	1971