Ferriheme is transferred from Methemoglobin to Hemopexin

Stable Identifier
R-HSA-2168884
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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When haptoglobin capacity to buffer hemoglobin is overwhelmed, hemoglobin undergoes a rapid conversion to methemoglobin. Ferriheme is transferred directly from methemoglobin to hemopexin (Miller et al. 1996, Mauk and Mauk 2010).

Literature References
PubMed ID Title Journal Year
20430887 Metal ions and electrolytes regulate the dissociation of heme from human hemopexin at physiological pH

Mauk, MR, Mauk, AG

J Biol Chem 2010
8855948 Role of hemopexin in protection of low-density lipoprotein against hemoglobin-induced oxidation

Miller, YI, Smith, A, Morgan, WT, Shaklai, N

Biochemistry 1996
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