Ferriheme is transferred from Methemoglobin to Hemopexin

Stable Identifier
R-HSA-2168884
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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Ferriheme is transferred from Methemoglobin to Hemopexin
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When haptoglobin capacity to buffer hemoglobin is overwhelmed, hemoglobin undergoes a rapid conversion to methemoglobin. Ferriheme is transferred directly from methemoglobin to hemopexin (Miller et al. 1996, Mauk and Mauk 2010).
Literature References
PubMed ID Title Journal Year
8855948 Role of hemopexin in protection of low-density lipoprotein against hemoglobin-induced oxidation

Smith, A, Morgan, WT, Shaklai, N, Miller, YI

Biochemistry 1996
20430887 Metal ions and electrolytes regulate the dissociation of heme from human hemopexin at physiological pH

Mauk, AG, Mauk, MR

J Biol Chem 2010
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Orthologous Events
Ferriheme is transferred from Methemoglobin to Hemopexin (Bos taurus)
Ferriheme is transferred from Methemoglobin to Hemopexin (Mus musculus)
Ferriheme is transferred from Methemoglobin to Hemopexin (Rattus norvegicus)
Ferriheme is transferred from Methemoglobin to Hemopexin (Sus scrofa)
Ferriheme is transferred from Methemoglobin to Hemopexin (Xenopus tropicalis)
Authored
May, B  (2012-03-21)
Reviewed
Tolosano, E  (2013-02-13)
Moestrup, SK  (2013-02-18)
Fiorito, V  (2013-02-13)
Created
May, B  (2012-03-25)
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