Reactome | Haptoglobin:Hemoglobin binds CD163

Haptoglobin:Hemoglobin binds CD163

Stable Identifier

R-HSA-2168883

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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The CD163 receptor binds the haptoglobin:hemoglobin complex (Kristiansen et al. 2001, Madsen et al. 2004, Nielsen et al. 2007). After binding, the CD163:haptoglobin:hemoglobin complex is internalized by endocytosis and is degraded in the lysosome. CD163 is found on the membranes of monocytes and macrophages.

Literature References

PubMed ID	Title	Journal	Year
17102136	A unique loop extension in the serine protease domain of haptoglobin is essential for CD163 recognition of the haptoglobin-hemoglobin complex Nielsen, MJ, Petersen, SV, Jacobsen, C, Thirup, S, Enghild, JJ, Graversen, JH, Moestrup, SK	J Biol Chem	2007
11196644	Identification of the haemoglobin scavenger receptor Kristiansen, M, Graversen, JH, Jacobsen, C, Sonne, O, Hoffman, HJ, Law, SK, Moestrup, SK	Nature	2001
15448162	Molecular characterization of the haptoglobin.hemoglobin receptor CD163. Ligand binding properties of the scavenger receptor cysteine-rich domain region Madsen, M, Møller, HJ, Nielsen, MJ, Jacobsen, C, Graversen, JH, van den Berg, T, Moestrup, SK	J Biol Chem	2004