Haptoglobin:Hemoglobin binds CD163

Stable Identifier
R-HSA-2168883
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The CD163 receptor binds the haptoglobin:hemoglobin complex (Kristiansen et al. 2001, Madsen et al. 2004, Nielsen et al. 2007). After binding, the CD163:haptoglobin:hemoglobin complex is internalized by endocytosis and is degraded in the lysosome. CD163 is found on the membranes of monocytes and macrophages.

Literature References
PubMed ID Title Journal Year
11196644 Identification of the haemoglobin scavenger receptor

Kristiansen, M, Graversen, JH, Jacobsen, C, Sonne, O, Hoffman, HJ, Law, SK, Moestrup, SK

Nature 2001
17102136 A unique loop extension in the serine protease domain of haptoglobin is essential for CD163 recognition of the haptoglobin-hemoglobin complex

Nielsen, MJ, Petersen, SV, Jacobsen, C, Thirup, S, Enghild, JJ, Graversen, JH, Moestrup, SK

J Biol Chem 2007
15448162 Molecular characterization of the haptoglobin.hemoglobin receptor CD163. Ligand binding properties of the scavenger receptor cysteine-rich domain region

Madsen, M, Møller, HJ, Nielsen, MJ, Jacobsen, C, Graversen, JH, van den Berg, T, Moestrup, SK

J Biol Chem 2004
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